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1. (WO2018035496) MACROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME

Pub. No.:    WO/2018/035496    International Application No.:    PCT/US2017/047675
Publication Date: Fri Feb 23 00:59:59 CET 2018 International Filing Date: Sat Aug 19 01:59:59 CEST 2017
IPC: A61K 38/04
A61K 47/30
C07K 14/60
Applicants: THE REASEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
Inventors: GONG, Bing
Title: MACROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME
Abstract:
Provided are macrocyclic compounds having one or more transmembrane segment-thermoresponsive segment moiety. Also provided are dimers comprising two macrocyclic units, which have one or more transmembrane segment-thermoresponsive segment moiety, joined by one or more crosslinking moieties. The macrocyclic compounds and macrocyclic units have a macrocyclic backbone comprise alternating alpha amino acid and meta-aminobenzoic acid moieties. The macrocyclic compounds and dimers can be used to deliver a cargo (e.g., cell-interacting agents such as, for example, drugs and cryoprotectants) to, for example, an organ, tissue, or an individual, A cargo may be encapsulated in lipid vesicles.