Search International and National Patent Collections

1. (WO2018035424) BIFUNCTIONAL ANTIFUNGAL AGENTS AND METHODS OF TREATING FUNGAL INFECTION

Pub. No.:    WO/2018/035424    International Application No.:    PCT/US2017/047536
Publication Date: Fri Feb 23 00:59:59 CET 2018 International Filing Date: Sat Aug 19 01:59:59 CEST 2017
IPC: C07D 403/12
C07D 251/68
A61K 31/53
A61K 31/10
Applicants: YALE UNIVERSITY
MERCK SHARP & DOHME CORP.
Inventors: SPIEGEL, David, A.
CHIRKIN, Egor
ROEMER, Terry
NANTERMET, Philippe
Title: BIFUNCTIONAL ANTIFUNGAL AGENTS AND METHODS OF TREATING FUNGAL INFECTION
Abstract:
The present invention is directed to bifunctional compounds which are useful in the treatment of fungal infections. The present compounds contains at least one fungal binding moiety (FBM) which is linked to at least one antibody binding moiety (ΑBΜ or ABT group) through a linker group, which optionally comprises a connector group. Compounds accordirig to the present invention are useful in the treatment of fungal infections as described herein.