Search International and National Patent Collections

1. (WO2018035416) REAGENTS AND METHODS FOR GLYCOSYLATION

Pub. No.:    WO/2018/035416    International Application No.:    PCT/US2017/047519
Publication Date: Fri Feb 23 00:59:59 CET 2018 International Filing Date: Sat Aug 19 01:59:59 CEST 2017
IPC: A61K 31/7034
A61Q 19/00
Applicants: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
Inventors: APONICK, Aaron
LIU, Ji
MIOTTO, Romain, J.
Title: REAGENTS AND METHODS FOR GLYCOSYLATION
Abstract:
The invention provides methods and regents for the glycosylation of organic molecules. In one aspect, the invention provides a method for glycosylating a hydroxyl-containing organic compound (i.e., a glycosyl acceptor) comprising contacting a glycosyl donor with the hydroxyl-containing organic compound, in the presence of an oxidant, to yield a glycosylated organic compound. In certain embodiments, the methods provided herein provide glycosylation products with high anomeric selectivity. The methods can be applied to the synthesis of disaccharides, trisaccharides, polysaccharides, glycans, etc. Also provided herein are compounds (e.g., glycosyl donors and acceptors) which are useful building blocks in the provided reactions.