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1. (WO2018035408) METHODS OF TREATING DEVELOPMENTAL DISORDERS WITH BIGUANIDES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/035408 International Application No.: PCT/US2017/047505
Publication Date: 22.02.2018 International Filing Date: 18.08.2017
IPC:
A61K 9/20 (2006.01) ,A61K 31/155 (2006.01) ,A61P 3/10 (2006.01) ,C07C 279/26 (2006.01)
Applicants: OVID THERAPEUTICS INC.[US/US]; 1460 Broadway New York, NY 10036, US
Inventors: DURING, Matthew; US
Agent: STEEN, Jeffrey, S.; US
CARTER, David M.; US
DELUCA, Peter; US
FARRELL, Raymond E.; US
SCHMIDT, Joseph W.; US
BREW, Michael R.; US
ROSSELLI, Thomas M.; US
Priority Data:
62/376,48818.08.2016US
Title (EN) METHODS OF TREATING DEVELOPMENTAL DISORDERS WITH BIGUANIDES
(FR) MÉTHODES DE TRAITEMENT DE TROUBLES DU DÉVELOPPEMENT AVEC LES BIGUANIDES
Abstract:
(EN) Methods of treating developmental disorders such as Angelman syndrome, Fragile X syndrome, Fragile X-associated tremor/ataxia syndrome (FXTAS), Autistic Spectrum Disorder, Autism, Asperger's syndrome, pervasive developmental disorder, Childhood Disintegrative Disorder, Rett syndrome, Landau-Kleffner Syndrome, Prader-Willi Syndrome, Tardive Dyskinesia, a seizure disorder and/or Williams Syndrome with a biguanide such as metformin, buformin, phenformin or a pharmaceutically acceptable salt thereof are provided. The methods provide therapeutic compositions that may be used to improve one or more symptoms of the developmental disorder.
(FR) L'invention concerne des méthodes de traitement de troubles du développement tels que le syndrome d'Angelman, le syndrome du chromosome X fragile, le syndrome du tremblement/ataxie associé à l'X Fragile (FXTAS), les troubles du spectre de l'autisme, l'autisme, le syndrome d'Asperger, les troubles envahissants du développement, les troubles désintégratifs de l'enfance, le syndrome de Rett, le syndrome de Landau-Kleffner, le syndrome de Prader-Willi, les dyskinésies tardives, les troubles épileptiques et/ou le syndrome de Williams avec le biguanide tel que metformine, buformine, phenformine ou un sel de qualité pharmaceutique de celui-ci. Les méthodes fournissent des compositions thérapeutiques qui peuvent être utilisées pour améliorer un ou plusieurs symptômes des troubles du développement.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)