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1. (WO2018035294) METHOD OF INDUCING AN ONCOLYTIC EFFECT ON TUMOR CELLS USING ZIKA VIRUS
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Pub. No.: WO/2018/035294 International Application No.: PCT/US2017/047295
Publication Date: 22.02.2018 International Filing Date: 17.08.2017
IPC:
A61K 35/768 (2015.01) ,C12N 7/00 (2006.01)
[IPC code unknown for A61K 35/768]
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7
Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
Applicants:
CEDARS-SINAI MEDICAL CENTER [US/US]; 8700 Beverly Blvd. Los Angeles, California 90048, US
Inventors:
ARUMUGASWAMI, Vaithilingaraja; US
BREUNIG, Joshua; US
Agent:
HUBER, Linda B.; US
BIRKENEDER, Erik J.; US
CHEN, Stephen, W.; US
COSTELLIA, Jeffrey; US
EISENSTEIN, Ronald, I.; US
GARETTO, Janet, M.; US
GATZ, Robert; US
KIM, Sean; US
LEVY, Seth D.; US
MATTAN-HUNG, Natalia; US
PROMMER, Peter J.; US
RESNICK, David S.; US
RITCHIE,, David B.; US
SWIATEK, Maria; US
TANG, Wayne L.; US
VAKHARIA-RAO, Hema; US
HAYES, Jennifer; US
Priority Data:
62/376,68918.08.2016US
Title (EN) METHOD OF INDUCING AN ONCOLYTIC EFFECT ON TUMOR CELLS USING ZIKA VIRUS
(FR) MÉTHODE D'INDUCTION D'UN EFFET ONCOLYTIQUE SUR DES CELLULES TUMORALES À L'AIDE DU VIRUS ZIKA
Abstract:
(EN) The present invention provide for methods of inducing an oncolytic effect on tumor cells using Zika virus. The invention also provides for inducing an oncolytic effect on brain tumors and treating brain tumors, and in particular, glioblastomas and neuroblastoma. The treatment involves the administration of Zika virus, which has an oncolytic effect on the tumor cells.
(FR) La présente invention concerne des méthodes d'induction d'un effet oncolytique sur des cellules tumorales à l'aide du virus Zika. L'invention concerne également des méthodes permettant d'induire un effet oncolytique sur des tumeurs du cerveau et de traiter des tumeurs du cerveau, et en particulier des glioblastomes et le neuroblastome. Le traitement implique l'administration du virus Zika, qui a un effet oncolytique sur les cellules tumorales.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)