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1. (WO2018035271) USE OF MILD ELECTROPHILES TO REDUCE ARTIFACTS IN ANALYZING GLYCANS RELEASED FROM GLYCOPROTEINS OR GLYCOPEPTIDES

Pub. No.:    WO/2018/035271    International Application No.:    PCT/US2017/047229
Publication Date: Fri Feb 23 00:59:59 CET 2018 International Filing Date: Thu Aug 17 01:59:59 CEST 2017
IPC: G01N 21/76
Applicants: PROZYME, INC.
Inventors: KIMZEY, Michael J.
Title: USE OF MILD ELECTROPHILES TO REDUCE ARTIFACTS IN ANALYZING GLYCANS RELEASED FROM GLYCOPROTEINS OR GLYCOPEPTIDES
Abstract:
The presence of mild electrophiles, such as aldehydes, during the denaturation of glycoproteins or glycopeptides and subsequent enzymatic deglycosylation reduces artifacts in subsequent analyses of the glycans released from the glycoproteins or glycopeptides.