WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2018035253) COMPOSITIONS AND METHODS FOR CARDIAC REPAIR
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/035253    International Application No.:    PCT/US2017/047200
Publication Date: 22.02.2018 International Filing Date: 16.08.2017
IPC:
A61K 48/00 (2006.01), C12N 15/00 (2006.01), A61K 38/00 (2006.01), C07H 21/04 (2006.01)
Applicants: CHILDREN'S MEDICAL CENTER CORPORATION [US/US]; 55 Shattuck Street Boston, Massachusetts 02115 (US)
Inventors: PU, William; (US).
LIN, Zhiqiang; (US)
Agent: HUNTER-ENSOR, PH.D., Melissa; (US)
Priority Data:
62/375,799 16.08.2016 US
Title (EN) COMPOSITIONS AND METHODS FOR CARDIAC REPAIR
(FR) COMPOSITIONS ET MÉTHODES DE RÉPARATION DU TISSU CARDIAQUE
Abstract: front page image
(EN)The present invention features compositions comprising a modified RNA encoding a Yes-associated protein (YAP) polypeptide and methods of using such compositions for cardiac repair. In particular embodiments, a modified RNA encoding a YAP polypeptide is administered in combination with an agent that reduces YAP degradation, such as a small molecule E64d.
(FR)La présente invention concerne des compositions comprenant un ARN modifié codant pour un polypeptide à protéine associée à Yes (YAP), et des méthodes d'utilisation de telles compositions pour une réparation cardiaque. Dans des modes de réalisation particuliers, un ARN modifié codant pour un polypeptide YAP est administré en combinaison avec un agent qui réduit la dégradation YAP, notamment une petite molécule E64d.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)