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1. (WO2018035246) GABA(A) RECEPTOR MODULATORS AND METHODS TO CONTROL AIRWAY HYPERRESPONSIVENESS AND INFLAMMATION IN ASTHMA
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/035246    International Application No.:    PCT/US2017/047185
Publication Date: 22.02.2018 International Filing Date: 16.08.2017
IPC:
C07D 487/04 (2006.01), C07D 487/14 (2006.01), A61K 31/5517 (2006.01), A61P 11/00 (2006.01)
Applicants: UWM RESEARCH FOUNDATION, INC. [US/US]; 1440 East North Avenue Milwaukee, WI 53202 (US).
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US/US]; Office of The General Counsel 412 Low Library, Mail Code 4308, 535 West 116th Street New York, NY 10027 (US)
Inventors: ARNOLD, Alexander, E.; (US).
STAFFORD, Douglas, C.; (US).
COOK, James, M.; (US).
EMALA, Charles, W.; (US).
FORKUO, Gloria; (US).
JAHAN, Rajwana; (US).
KODALI, Revathi; (US).
LI, Guanguan; (US).
STEPHEN, Michael, Rajesh; (US)
Agent: CARROLL, William, A.; (US).
REYNOLDS, Anne, M.; (US).
RIZZUTO, Kevin, P.; (US).
YAN, Wei; (US).
HARTWIG, Kevin, P.; (US).
LANGER, Michael, R.; (US)
Priority Data:
62/375,694 16.08.2016 US
62/427,771 29.11.2016 US
Title (EN) GABA(A) RECEPTOR MODULATORS AND METHODS TO CONTROL AIRWAY HYPERRESPONSIVENESS AND INFLAMMATION IN ASTHMA
(FR) MODULATEURS DU RÉCEPTEUR GABA(A) ET PROCÉDÉS DE CONTRÔLE DE L'HYPERRÉACTIVITÉ DES VOIES RESPIRATOIRES ET DE L'INFLAMMATION DANS L'ASTHME
Abstract: front page image
(EN)Pyrrolobenzodiazepines target alpha-4 and alpha-5 GABAA receptors for use in the treatment of airway hyperresponsiveness and inflammation in asthma. Compounds selectively partition to the peripheral compartment and have reduced CNS effects.
(FR)Les pyrrolobenzodiazépines ciblent les récepteurs alpha-4 et alpha-5 GABAA destinés à être utilisés dans le traitement de l'hyperréactivité des voies respiratoires et de l'inflammation dans l'asthme. Les composés se séparent sélectivement au compartiment périphérique et ont des effets de SNC réduits.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)