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1. (WO2018035079) HUMAN GHRELIN O-ACYL TRANSFERASE INHIBITORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/035079    International Application No.:    PCT/US2017/046863
Publication Date: 22.02.2018 International Filing Date: 15.08.2017
IPC:
A61K 31/56 (2006.01), A61K 31/565 (2006.01), C07J 41/00 (2006.01), C07J 51/00 (2006.01)
Applicants: HOUGLAND, James, L. [US/US]; (US).
CHISHOLM, John, D. [US/US]; (US)
Inventors: HOUGLAND, James, L.; (US).
CHISHOLM, John, D.; (US)
Agent: PRICE, Frederick, JM; (US).
NOTO, Joseph, M.; (US).
BETTINGER, Blaine; (US).
MCGUIRE, George, R.; (US).
NOCILLY, David, L.; (US)
Priority Data:
62/375,699 16.08.2016 US
Title (EN) HUMAN GHRELIN O-ACYL TRANSFERASE INHIBITORS
(FR) INHIBITEURS DE LA GHRÉLINE O-ACYL TRANSFÉRASE HUMAINE
Abstract: front page image
(EN)A class of cyanosteroid compounds that efficiently inhibit ghrelin acylation by ghrelin O-acyltransferase. The compounds have a steroid scaffold with α,β-unsaturated ketone in the A ring position such an a-cyanoenone. Exemplary compounds include (5S,8S,9S,10S, 13S,14S)-10,13-dimethyl-3-oxo-4,5,6,7,8,9,10,11,12,13,14,15,16,17- tetradecahydro-3H-cyclopenta[a]phenanthrene-2-carbonitrile.
(FR)L'invention concerne une classe de composés cyanostéroïdes qui inhibent efficacement l'acylation de la ghréline par la ghréline O-acyltransférase. Les composés ont un squelette stéroïde avec une cétone α,β non saturée dans la position du cycle A telle qu'une a-cyanoénone. Des exemples de composés comprennent le (5S,8S,9S, 13S, 13S,14S)-10,13-diméthyl-3-oxo -4,5,6,7,8,9,10,11,12,13,14,15,16,17-tétradécahydro-3 H-cyclopenta[a]phénanthrène-2-carbonitrile.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)