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1. (WO2018035018) METHODS TO EXPAND THE SPECTRUM OF GRAM-POSITIVE ANTIBIOTICS

Pub. No.:    WO/2018/035018    International Application No.:    PCT/US2017/046712
Publication Date: Fri Feb 23 00:59:59 CET 2018 International Filing Date: Tue Aug 15 01:59:59 CEST 2017
IPC: A61K 31/41
A61K 31/4164
A61L 31/08
Applicants: NORTH CAROLINA STATE UNIVERSITY
Inventors: MELANDER, Christian
MELANDER, Roberta
Title: METHODS TO EXPAND THE SPECTRUM OF GRAM-POSITIVE ANTIBIOTICS
Abstract:
Provided herein is a method to treat a Gram-negative bacterial infection in a subject in need thereof, comprising administering a compound of Formula I: in combination with a Gram-positive antibiotic to said subject in a treatment-effective amount. Also provided is a method to control Gram-negative bacteria, comprising applying a compound of Formula I in combination with a Gram-positive antibiotic in a Gram-negative bactericidal-effective amount.