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1. (WO2018034901) N-CARBOXYANHYDRIDE-BASED-SCALE SYNTHESIS OF ELAMIPRETIDE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/034901    International Application No.:    PCT/US2017/046021
Publication Date: 22.02.2018 International Filing Date: 09.08.2017
IPC:
A61K 38/07 (2006.01), C07K 1/02 (2006.01), C07K 5/10 (2006.01)
Applicants: STEALTH BIOTHERAPEUTICS [US/US]; 275 Grove Street 3-107 Newton, MA 02466 (US)
Inventors: DUNCAN, Scott M.; (US).
OUDENES, Jan; (CA).
ANDERSEN, Marc W.; (US)
Agent: GORDON, Dana M.; (US).
AKHIEZER, Alexander; (US).
ABELLEIRA, Susan, M.; (US).
CHOI, Philip, S.; (US).
BLOUNT, Jennefer; (US)
Priority Data:
62/375,579 16.08.2016 US
Title (EN) N-CARBOXYANHYDRIDE-BASED-SCALE SYNTHESIS OF ELAMIPRETIDE
(FR) SYNTHÈSE D'ÉCHELLE D'ELAMIPRETIDE À BASE DE N-CARBOXYANHYDRIDE
Abstract: front page image
(EN)Disclosed are methods of making elamipretide (MTP-131), a peptide compound with therapeutic potential for treating various mitochondrial myopathies. The synthesis of the peptide can be achieved via the use of N-carboxyanhydride-modified amino acid residues, which increases the efficiency of the synthetic process and the purity of the peptide product generated.
(FR)L'invention concerne des procédés de fabrication d'elamipretide (MTP -131), un composé peptidique ayant un potentiel thérapeutique pour traiter diverses myopathies mitochondriales. La synthèse du peptide peut être obtenue par l'utilisation de résidus d'acides aminés modifiés par N-carboxyanhydride, ce qui augmente l'efficacité du processus synthétique et la pureté du produit peptidique généré.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)