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1. (WO2018034523) COMPOSITION FOR SUPPRESSING IMMUNE RESPONSE, CONTAINING JAK INHIBITOR
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Pub. No.: WO/2018/034523 International Application No.: PCT/KR2017/008989
Publication Date: 22.02.2018 International Filing Date: 17.08.2017
IPC:
A61K 31/519 (2006.01) ,A61K 45/06 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Applicants:
서울대학교 산학협력단 SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION [KR/KR]; 서울시 관악구 관악로 1 1, Gwanak-ro Gwanak-gu Seoul 08826, KR
Inventors:
박정규 PARK, Chung Gyu; KR
김정식 KIM, Jung Sik; KR
김종민 KIM, Jong Min; KR
신준섭 SHIN, Jun Seop; KR
강성준 KANG, Seong Jun; KR
윤일희 YOON, Il Hee; KR
민병훈 MIN, Byoung Hoon; KR
Agent:
김순웅 KIM, Soon Woong; KR
Priority Data:
10-2016-010446117.08.2016KR
Title (EN) COMPOSITION FOR SUPPRESSING IMMUNE RESPONSE, CONTAINING JAK INHIBITOR
(FR) COMPOSITION POUR INHIBER LA RÉPONSE IMMUNITAIRE, CONTENANT UN INHIBITEUR DE JAK
(KO) JAK 억제제를 포함하는 면역반응 억제용 조성물
Abstract:
(EN) The present invention relates to a composition for suppressing an immune response, containing a Janus Kinase (JAK) inhibitor, and a composition for protecting the pancreatic islet, containing a JAK inhibitor. The composition of the present invention has an excellent effect of suppressing blood- and cell-mediated immune responses, including instant blood mediated inflammatory reaction (IBMIR), which is the main cause of pancreatic islet loss, and, unlike traditional immunosuppressants, has effects of maintaining the function of the pancreatic islet and promoting the survival rate of the pancreatic islet, thereby being usable in the suppression of an immune response and the protection of pancreatic islet cells during the xenotransplantation of the pancreatic islet.
(FR) La présente invention concerne une composition pour inhiber la réponse immunitaire, contenant un inhibiteur de la kinase Janus (JAK), et une composition pour protéger les îlots pancréatiques, contenant un inhibiteur de la JAK. La composition de la présente invention a un excellent effet d'inhibition des réponses immunitaires à médiation humorale et cellulaire, y compris de la réponse inflammatoire précoce médiée par le sang (IBMIR), qui est la cause principale de la perte des îlots pancréatiques, et, contrairement aux immunosuppresseurs classiques, a comme effets de maintenir la fonction de l'îlot pancréatique et de favoriser le taux de survie de l'îlot pancréatique, pouvant de ce fait être utilisée pour inhiber la réponse immunitaire et protéger les cellules des îlots pancréatiques lors de xénogreffes d'îlots pancréatiques.
(KO) 본 발명은 JAK(Janus Kinase) 억제제를 포함하는 면역반응 억제용 조성물, JAK(Janus Kinase) 억제제를 포함하는 췌도 보호용 조성물에 관한 것이다. 본 발명의 조성물은 췌도의 주요소실원인인 즉각성 혈액매개성 염증반응(IBMIR)을 포함한 혈액 및 세포매개성 면역반응 억제효과가 우수할 뿐만 아니라, 기존의 면역억제제와 달리 췌도의 기능유지 및 췌도의 생존률을 향상시키는 효과가 있으므로 이종간 췌도 이식시 면역반응 억제 및 췌도 세포의 보호에 유용하게 사용할 수 있다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)