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1. WO2018034453 - CONJUGATE OF MINOXIDIL AND PEPTIDE

Publication Number WO/2018/034453
Publication Date 22.02.2018
International Application No. PCT/KR2017/008428
International Filing Date 04.08.2017
IPC
A61K 47/50 2017.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
A61K 8/49 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
49containing heterocyclic compounds
A61K 31/506 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506not condensed and containing further heterocyclic rings
A61Q 7/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
7Preparations for affecting hair growth
C07K 7/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
C07K 7/08 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
08having 12 to 20 amino acids
CPC
A61K 2800/57
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2800Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
40Chemical, physico-chemical or functional or structural properties of particular ingredients
57Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances
A61K 31/506
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506not condensed and containing further heterocyclic rings
A61K 31/513
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
513having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
A61K 38/1709
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
1703from vertebrates
1709from mammals
A61K 47/50
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
A61K 47/64
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
Applicants
  • (주)케어젠 CAREGEN CO., LTD. [KR]/[KR]
Inventors
  • 정용지 CHUNG, Yong Ji
  • 김은미 KIM, Eun Mi
Agents
  • 특허법인 태평양 BAE, KIM & LEE IP GROUP
Priority Data
10-2016-010570719.08.2016KR
Publication Language Korean (ko)
Filing Language Korean (KO)
Designated States
Title
(EN) CONJUGATE OF MINOXIDIL AND PEPTIDE
(FR) CONJUGUÉ DE MINOXIDIL ET D'UN PEPTIDE
(KO) 미녹시딜과 펩타이드의 결합체
Abstract
(EN) The present invention relates to a composition for preventing hair loss and, more specifically, to a compound having a structure in which minoxidil and a peptide are chemically connected, and to a pharmaceutical composition or cosmetic composition for preventing hair loss or promoting hair growth comprising the compound. The compound having a structure in which minoxidil and a peptide are chemically connected according to the present invention has not only excellent physiological activity such as hair loss reduction, hair growth promotion or cell growth promotion, but also excellent stability in water, and can therefore be useful as a composition for preventing hair loss and promoting hair growth.
(FR) La présente invention concerne une composition pour la prévention de la chute des cheveux et, plus spécifiquement, un composé présentant une structure dans laquelle du finastéride et un peptide sont liés par liaison covalente, et une composition pharmaceutique ou une composition cosmétique comprenant le composé et visant à prévenir la chute des cheveux ou à favoriser la pousse des cheveux. Le composé ayant une structure dans laquelle le minoxidil et un peptide sont reliés chimiquement selon la présente invention présente non seulement une excellente activité physiologique, telle qu'une diminution de la perte des cheveux, une promotion de la pousse des cheveux ou une promotion de la croissance cellulaire, mais également une excellente stabilité dans l'eau, et peut donc être utilisable en tant que composition pour prévenir la chute des cheveux et favoriser la pousse des cheveux.
(KO) 본 발명은 탈모 방지용 조성물에 관한 것으로서, 보다 상세하게는 미녹시딜과 펩타이드가 화학적으로 연결된 구조를 갖는 화합물 및 이를 포함하는 탈모 방지 또는 발모 촉진용 약학적 조성물 또는 화장료 조성물에 관한 것이다. 본 발명의 미녹시딜과 펩타이드가 화학적으로 연결된 구조를 갖는 화합물은 탈모 개선, 발모 촉진, 세포 성장 촉진 등과 같은 생리활성이 우수할 뿐만 아니라 물에서의 안정성이 우수하므로, 탈모 방지 및 발모 촉진용 조성물로서 유용하게 사용될 수 있다.
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