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1. (WO2018034298) GENETICALLY-MODIFIED TRYPANOSOMA CRUZI HAVING CALCIUM INDICATOR, AND APPLICATION OF SAID TRYPANOSOMA CRUZI FOR SCREENING OF ANTI-TRYPANOSOME AGENT

Pub. No.:    WO/2018/034298    International Application No.:    PCT/JP2017/029418
Publication Date: Fri Feb 23 00:59:59 CET 2018 International Filing Date: Thu Aug 17 01:59:59 CEST 2017
IPC: C12N 1/11
C12N 15/09
C12Q 1/02
Applicants: RIKEN
国立研究開発法人理化学研究所
Inventors: MIKOSHIBA Katsuhiko
御子柴 克彦
NARA Takeshi
奈良 武司
HASHIMOTO Muneaki
橋元 宗明
Title: GENETICALLY-MODIFIED TRYPANOSOMA CRUZI HAVING CALCIUM INDICATOR, AND APPLICATION OF SAID TRYPANOSOMA CRUZI FOR SCREENING OF ANTI-TRYPANOSOME AGENT
Abstract:
The present invention provides a genetically-modified Trypanosoma cruzi having a calcium indicator, and an application of said Trypanosoma cruzi for screening of an anti-trypanosome agent. More specifically, the present invention provides: a genetically-modified Trypanosoma cruzi having, in the body thereof, an intracellular calcium indicator that includes a fused protein of a mammal-derived calmodulin, a myosin light chain kinase-derived peptide (M13 peptide), and a marker protein; and a screening method of an anti-trypanosome agent in which said Trypanosoma cruzi is used.