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1. (WO2018033929) DIAGNOSTIC AND THERAPEUTIC USES OF EXOSOMES

Pub. No.:    WO/2018/033929    International Application No.:    PCT/IL2017/050922
Publication Date: Fri Feb 23 00:59:59 CET 2018 International Filing Date: Sat Aug 19 01:59:59 CEST 2017
IPC: C12Q 1/68
C12Q 1/48
G01N 33/53
A61K 39/395
A61K 31/7088
A61K 31/713
A61K 35/12
Applicants: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventors: WALLACH, David
KOVALENKO, Andrew
YOON, Seongmin
Title: DIAGNOSTIC AND THERAPEUTIC USES OF EXOSOMES
Abstract:
A method of detecting activation of a necroptosis activation pathway in a subject is disclosed. The method comprising: (a) obtaining a biological sample comprising exosomes from the subject; (b) detecting an activity or expression of a component of the necroptosis activation pathway in an exosome fraction of the biological sample, wherein an increase in the activity or expression of the component of the necroptosis activation pathway indicates the activation of said necroptosis activation pathway. Methods of diagnosing necroptosis or inflammation by determining the level of exosomes in a biological sample. Method of modulating endocytosis by inhibiting MLKL or a cell surface receptor and a pharmaceutical composition comprising a population of exosomes comprising a component of the necroptosis activation pathway and its use in therapy of diseases, such as inflammation and cancer.