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1. (WO2018033815) PYRIDOPYRIMDINONE CDK2/4/6 INHIBITORS

Pub. No.:    WO/2018/033815    International Application No.:    PCT/IB2017/054655
Publication Date: Fri Feb 23 00:59:59 CET 2018 International Filing Date: Tue Aug 01 01:59:59 CEST 2017
IPC: C07D 471/04
A61P 35/00
Applicants: PFIZER INC.
Inventors: BEHENNA, Douglas Carl
CHEN, Ping
FREEMAN-COOK, Kevin Daniel
HOFFMAN, Robert Louis
JALAIE, Mehran
NAGATA, Asako
NAIR, Sajiv Krishnan
NINKOVIC, Sacha
ORNELAS, Martha Alicia
PALMER, Cynthia Louise
RUI, Eugene Yuanjin
Title: PYRIDOPYRIMDINONE CDK2/4/6 INHIBITORS
Abstract:
This invention relates to compounds of general Formula (I), and pharmaceutically acceptable salts thereof, in which R1, R2, R2A, R2B, R3, R4, R5A, R5B, R6, R7, R8, R9, p, q and r are as defined herein, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.