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1. (WO2018033730) CLOSED LINEAR DNA PRODUCTION

Pub. No.:    WO/2018/033730    International Application No.:    PCT/GB2017/052413
Publication Date: Fri Feb 23 00:59:59 CET 2018 International Filing Date: Thu Aug 17 01:59:59 CEST 2017
IPC: C12Q 1/68
Applicants: TOUCHLIGHT IP LIMITED
Inventors: ADIE, Thomas
PORTER, Neil
ROTHWELL, Paul
Title: CLOSED LINEAR DNA PRODUCTION
Abstract:
The present invention relates to improved processes for production of closed linear deoxyribonucleic acid (DNA), in particular cell-free enzymatic production of closed linear DNA molecules, preferably using a closed linear DNA as a template for DNA synthesis. The invention further relates to a novel closed linear DNA species, suitable for use as a template in the improved processes for production of closed linear DNA. Further, the invention pertains to the intermediate products of the processes, since this enables the production of larger quantities of closed linear DNA from the template than with methods known in the art.