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1. (WO2018033570) COMPOSITION COMPRISING SELF-ASSEMBLING PEPTIDES FOR USE IN TREATMENT OF GINGIVITIS, PERIODONTITIS AND/OR PERI-IMPLANTITIS
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Pub. No.: WO/2018/033570 International Application No.: PCT/EP2017/070758
Publication Date: 22.02.2018 International Filing Date: 16.08.2017
IPC:
A61K 38/08 (2006.01) ,A61P 31/04 (2006.01) ,A61P 29/00 (2006.01) ,A61P 1/02 (2006.01) ,A61K 9/00 (2006.01) ,A61L 31/14 (2006.01) ,A61Q 11/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08
Peptides having 5 to 11 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
02
Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31
Materials for other surgical articles
14
Materials characterised by their function or physical properties
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
Q
SPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
11
Preparations for care of the teeth, of the oral cavity or of dentures, e.g. dentifrices or toothpastes; Mouth rinses
Applicants:
CREDENTIS AG [CH/CH]; Dorfstrasse 69 5210 Windisch, CH
Inventors:
HUG, Michael; CH
LYSEK, Dominikus Amadeus; CH
KOCH, Franziska; DE
JUNG, Ronald; CH
MATHES, Stephanie; CH
MEYER, Nina; CH
HÄMMERLE, Christoph; CH
BRÖSELER, Frank; DE
PIELES, Uwe; DE
Agent:
MORÉ, Solveig; Kroher Strobel Rechts- und Patentanwälte PartmbB Bavariaring 20 80336 München, DE
Priority Data:
16184309.916.08.2016EP
16200655.525.11.2016EP
Title (EN) COMPOSITION COMPRISING SELF-ASSEMBLING PEPTIDES FOR USE IN TREATMENT OF GINGIVITIS, PERIODONTITIS AND/OR PERI-IMPLANTITIS
(FR) COMPOSITION COMPRENANT DES PEPTIDES À AUTO-ASSEMBLAGE DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT DE LA GINGIVITE, DE LA PARODONTITE ET/OU DE LA PÉRI-IMPLANTITE
Abstract:
(EN) The present invention provides a composition comprising specific self-assembling peptides, which are capable of self-assembly at a pH below 7.5 and at least physiologic ionic strength, e.g., PI 1-4. PI 1-8, PI 1-14, PI 1-13, PI 1-12, PI 1-28, PI 1-29, PI 1-2, PI 1-5, PI 1-17, PI 1-19, PI 1-20, PI 1-12, PI 1-16, PI 1-18, PI 1-26 or PI 1-31 for use in treating an oral disease selected from the group consisting of gingivitis, periodontitis and/or peri-implantitis in a subject. Said composition may be used, after suitable cleaning procedures, for filling pockets formed adjacent to teeth in said diseases, which enhances tissue regeneration. The composition may be suitable for controlled release of an active agent, e.g., an antimicrobial or antibiotic agent. The invention also provides a kit suitable for said treatment further comprising self-assembling peptides suitable for forming a second layer on top of the first composition.
(FR) La présente invention concerne une composition comprenant des peptides à auto-assemblage spécifiques, qui sont capables de s'auto-assembler à un pH inférieur à 7,5 et une force ionique au moins physiologique, par exemple PI 1-4, PI 1-8, PI 1-14, PI 1-13, PI 1-12, PI 1-28, PI 1-29, PI 1-2, PI 1-5, PI 1-17, PI 1-19, PI 1-20, PI 1-12, PI 1-16, PI 1-18, PI 1-26 ou PI 1-31 pour une utilisation dans le traitement d'une maladie buccale choisie dans le groupe constitué de la gingivite, de la parodontite et/ou de la péri-implantite chez un sujet. Ladite composition peut être utilisée, après des procédures de nettoyage appropriées, pour remplir des poches formées à proximité des dents dans lesdites maladies, ce qui améliore la régénération tissulaire. La composition peut être appropriée pour la libération contrôlée d'un agent actif, par exemple, un agent antimicrobien ou antibiotique. L'invention concerne également un kit approprié pour ledit traitement comprenant en outre des peptides à auto-assemblage appropriés pour former une seconde couche au-dessus de la première composition.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)