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1. (WO2018033556) NOVEL COMPOUNDS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/033556    International Application No.:    PCT/EP2017/070718
Publication Date: 22.02.2018 International Filing Date: 16.08.2017
IPC:
C07D 401/14 (2006.01), A61K 31/506 (2006.01), A61P 35/00 (2006.01)
Applicants: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED [GB/GB]; 980 Great West Road Brentford Middlesex TW8 9GS (GB)
Inventors: HARLING, John David; (GB).
TINWORTH, Christopher; (GB)
Agent: LEAROYD, Stephanie Anne; (GB)
Priority Data:
1614134.3 18.08.2016 GB
Title (EN) NOVEL COMPOUNDS
(FR) NOUVEAUX COMPOSÉS
Abstract: front page image
(EN)A method of treating disorders associated with aberrant kinase activity, wherein the kinase is. Adaptor-associated protein kinase 1 (AAK1), Aurora Kinase A (AURKA), Aurora Kinase B (AURKB), Bruton's Tyrosine Kinase (BTK), Interleukin-1 receptor-associated kinase 3 (IRAK3), Protein tyrosine kinase 2 beta (PTK2B), Tyrosine-protein kinase Tec (TEC), Serine/threonine- protein kinase Wee1 (WEE1), Cyclin G-associated kinase (GAK), Large Tumour suppressor Kinase (LATS1),Focal Adhesion Kinase (PTK2), Ribosomal protein S6 kinase alpha-1 (RPS6KA1) said method comprising degrading said kinase.
(FR)L'invention porte sur une méthode de traitement de troubles associés à une activité kinase aberrante, où la kinase étant la protéine kinase 1 associée à l'adaptateur (AAK1), la kinase Aurora A (AURKA), la kinase Aurora B (AURKB), la tyrosine kinase de Bruton (BTK), la kinase 3 associée au récepteur de l'interleukine 1 (IRAK3), la protéine tyrosine kinase 2 bêta (PTK2B), la tyrosine-protéine kinase TEC (TEC), sérine/thréonine-protéine kinase wee1 (WEE1), kinase associée à la cycline G (GAK), grande kinase suppresseur de tumeur (LATS1), la kinase d'adhésion focale (PTK2), la protéine ribosomale s6 kinase alpha -1 (RPS6KA1), ledit procédé comprenant la dégradation de ladite kinase.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)