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1. (WO2018033126) USE OF VCP INHIBITOR AND ONCOLYTIC VIRUS IN THE PREPARATION OF AN ANTI-TUMOR DRUG
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/033126 International Application No.: PCT/CN2017/097969
Publication Date: 22.02.2018 International Filing Date: 18.08.2017
IPC:
A61K 45/06 (2006.01) ,A61K 48/00 (2006.01) ,A61K 35/768 (2015.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
[IPC code unknown for A61K 35/768]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants: GUANGZHOU VIROTECH PHARMACEUTICAL CO., LTD.[CN/CN]; Room 416-428, Guangzhou International Business Incubator G District No.3, Lanyue Road, Science Park, High-tech Industrial Development Zone Guangzhou, Guangdong 510663, CN
Inventors: YAN, Guangmei; CN
ZHANG, Haipeng; CN
LIN, Yuan; CN
LIN, Suizhen; CN
CAI, Jing; CN
GONG, Shoufang; CN
HU, Jun; CN
XIAO, Xiao; CN
LI, Kai; CN
LIANG, Jiankai; CN
TAN, Yaqian; CN
ZHU, Wenbo; CN
YIN, Wei; CN
Agent: WAN HUI DA INTELLECTUAL PROPERTY AGENCY; Yiyuan Office Building, Friendship Hotel, No. 1 Zhongguancun Street South, Haidian District Beijing 100873, CN
Priority Data:
201610688100.718.08.2016CN
Title (EN) USE OF VCP INHIBITOR AND ONCOLYTIC VIRUS IN THE PREPARATION OF AN ANTI-TUMOR DRUG
(FR) UTILISATION D'UN INHIBITEUR DE VCP ET D'UN VIRUS ONCOLYTIQUE DANS LA PRÉPARATION D'UN MÉDICAMENT ANTITUMORAL
Abstract:
(EN) Use of VCP (valosin-containing protein, VCP) inhibitor and oncolytic virus in the preparation of an anti-tumor drug. The present invention firstly discovers that VCP inhibitor can be used in the preparation of an anti-tumor synergist for oncolytic virus. Meanwhile, a pharmaceutical composition comprising VCP inhibitor and oncolytic virus, a pharmaceutical kit comprising VCP inhibitor and oncolytic virus, and use of VCP inhibitor and oncolytic virus for treating tumor. The present invention discloses an anti-tumor administration system, characterized in that, comprising oncolytic virus and a reagent for detecting the expression level of VCP.
(FR) L'invention concerne l'utilisation d'un inhibiteur de VCP (protéine contenant de la valosine, VCP) et d'un virus oncolytique dans la préparation d'un médicament antitumoral. La présente invention découvre tout d'abord que l'inhibiteur de VCP peut être utilisé dans la préparation d'un synergiste antitumoral du virus oncolytique. En même temps, l'invention concerne une composition pharmaceutique comprenant un inhibiteur de VCP et un virus oncolytique, une trousse pharmaceutique comprenant un inhibiteur de VCP et un virus oncolytique, et l'utilisation d'un inhibiteur de VCP et d'un virus oncolytique pour traiter une tumeur. La présente invention décrit un système d'administration antitumoral, caractérisé en ce qu'il comprend un virus oncolytique et un réactif pour la détection du niveau d'expression de VCP.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)