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1. (WO2018033118) ALL-TRANS RETINOIC ACID LIPOSOME PREPARATION, AND PREPARATION AND APPLICATION THEREOF
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Pub. No.: WO/2018/033118 International Application No.: PCT/CN2017/097869
Publication Date: 22.02.2018 International Filing Date: 17.08.2017
IPC:
A61K 9/127 (2006.01) ,A61K 31/203 (2006.01) ,A61K 47/40 (2006.01) ,A61K 47/34 (2017.01) ,A61K 47/32 (2006.01) ,A61K 47/38 (2006.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
20
having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid
203
Retinoic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
40
Cyclodextrins; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
34
Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
32
Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
38
Cellulose; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
上海交通大学 SHANGHAI JIAO TONG UNIVERSITY [CN/CN]; 中国上海市 闵行区东川路800号 No. 800 Dongchuan Road, Minghang District Shanghai 200240, CN
Inventors:
徐宇虹 XU, Yuhong; CN
郑安杰 ZHENG, Anjie; CN
陈晓龙 CHEN, Xiaolong; CN
Agent:
上海光华专利事务所 J.Z.M.C. PATENT AND TRADEMARK LAW OFFICE; 中国上海市 杨浦区国定路335号5022室余明伟 YU, Mingwei Room 5022, No. 335, Guo Ding Road, Yangpu District Shanghai 200433, CN
Priority Data:
201610686883.518.08.2016CN
Title (EN) ALL-TRANS RETINOIC ACID LIPOSOME PREPARATION, AND PREPARATION AND APPLICATION THEREOF
(FR) PRÉPARATION DE LIPOSOME D'ACIDE TOUT-TRANS RÉTINOÏQUE, SA PRÉPARATION ET SON APPLICATION
(ZH) 一种全反式维甲酸脂质体制剂及其制备与应用
Abstract:
(EN) An all-trans retinoic acid liposome preparation, and preparation and application thereof. The all-trans retinoic acid liposome preparation comprises an all-trans retinoic acid and a liposome carrier. The preparation method adopts an active drug loading method, comprising a calcium acetate gradient method or a sodium acetate gradient method. The all-trans retinoic acid preparation prepared has high drug loading and high in vivo stability, thereby improving the plasma concentration and extending the half-life of the all-trans retinoic acid.
(FR) L'invention concerne une préparation de liposome d'acide tout-trans rétinoïque, et sa préparation et son application. La préparation de liposome d'acide tout-trans rétinoïque comprend un acide tout-trans rétinoïque (Trétinoïne) et un support de liposome. Le procédé de préparation adopte un procédé de chargement de médicament actif, comprenant un procédé de gradient d'acétate de calcium ou un procédé de gradient d'acétate de sodium. La préparation d'acide tout-trans rétinoïque préparée présente une charge importante de médicament et une stabilité forte in vivo, ce qui permet d'améliorer la concentration plasmatique et d'allonger la demi-vie de l'acide tout-trans rétinoïque.
(ZH) 一种全反式维甲酸脂质体制剂及其制备方法。所述全反式维甲酸脂质体制剂包括全反式维甲酸和脂质体载体。其制备方法为主动载药法,包括醋酸钙梯度法或者醋酸钠梯度法。所制备的全反式维甲酸制剂载药量高、体内稳定,提高了全反式维甲酸的血药浓度,延长了半衰期。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)