WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2018032637) HIGHLY GLYCOSYLATED HUMAN BLOOD-CLOTTING FACTOR VIII FUSION PROTEIN, AND MANUFACTURING METHOD AND APPLICATION OF SAME
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/032637    International Application No.:    PCT/CN2016/106010
Publication Date: 22.02.2018 International Filing Date: 16.11.2016
IPC:
C07K 19/00 (2006.01), C12N 15/62 (2006.01), C12N 15/85 (2006.01), C12N 5/10 (2006.01), A61K 38/37 (2006.01), A61P 7/04 (2006.01)
Applicants: AMPSOURCE BIOPHARMA INC. [CN/CN]; Room 106, No.518 Bibo Road, Pudong New Area Shanghai 201203 (CN).
FUREN PHARMACEUTICAL GROUP CO., LTD. [CN/CN]; No.1 Tongyuan Road, Industrial Agglomeration Area, Luyi Zhoukou, Henan 477251 (CN).
PHARMAB, INC. [CN/CN]; Room 315, No.518 Bibo Road, Pudong New Area Shanghai 201203 (CN).
KAIFENG PHARMACEUTICAL (GROUP) CO., LTD. [CN/CN]; No.1 Yunan Street, Yuwangtai District Kaifeng, Henan 475003 (CN)
Inventors: LI, Qiang; (CN).
ZHU, Wenchen; (CN).
LI, Yuanli; (CN).
ZHU, Chenggong; (CN).
GAO, Yongjuan; (CN).
REN, Zijia; (CN).
ZHU, Luyan; (CN).
SUN, Naichao; (CN).
WANG, Xiaoshan; (CN).
LIU, Bin; (CN).
LI, Zhi; (CN).
WANG, Wenwen; (CN).
JIANG, Ming; (CN).
WANG, Qilei; (CN).
WANG, Lirui; (CN).
WANG, Shuya; (CN).
ZHU, Songlin; (CN).
GAO, Jie; (CN).
SU, Hongsheng; (CN)
Agent: BEYOND ATTORNEYS AT LAW; F6, Xijin Centre 39 Lianhuachi East Rd. Haidian District, Beijing 100036 (CN)
Priority Data:
201610692838.0 19.08.2016 CN
Title (EN) HIGHLY GLYCOSYLATED HUMAN BLOOD-CLOTTING FACTOR VIII FUSION PROTEIN, AND MANUFACTURING METHOD AND APPLICATION OF SAME
(FR) PROTÉINE DE FUSION DU FACTEUR VIII DE COAGULATION SANGUINE HUMAINE HAUTEMENT GLYCOSYLÉE, SON PROCÉDÉ DE FABRICATION ET SON APPLICATION
(ZH) 高糖基化人凝血因子VIII融合蛋白及其制备方法与用途
Abstract: front page image
(EN)A highly glycosylated human blood-clotting factor VIII (FVIII) fusion protein, and a manufacturing method and application of same. The fusion protein comprises, from the N-terminus to the C-terminus, a human (FVIII), a flexible peptide connector, at least one rigid unit of a human chorionic gonadotropin β-subunit carboxyl terminal peptide, and a half-life extending portion (preferentially selected from a human IgG Fc variant). The fusion protein has a similar level of biological activity as a recombinant (FVIII) and an extended in vivo half-life, thereby improving pharmacokinetics and drug efficacy.
(FR)L'invention concerne une protéine de fusion du facteur VIII (FVIII) de coagulation sanguine humaine hautement glycosylée, un procédé de fabrication et une application de celle-ci. La protéine de fusion comprend, de l'extrémité N-terminale à l'extrémité C-terminale, un FVIII humain, un connecteur peptidique flexible, au moins une unité rigide d'un peptide terminal carboxyle de sous-unité bêta de gonadotrophine chorionique humaine, et une partie d'extension de demi-vie (de préférence sélectionnée à partir d'une variante Fc d'IgG humaine). La protéine de fusion a un niveau similaire de l'activité biologique que du recombinant FVIII et une extension de demi-vie in vivo, améliorant ainsi la pharmacocinétique et l'efficacité des médicaments.
(ZH)一种高糖基化的重组人凝血因子VIII(FVIII)融合蛋白、其制备方法及用途。该融合蛋白从N端到C端依次包含人(FVIII)、柔性肽接头、至少1个人绒毛膜促性腺激素β亚基羧基末端肽刚性单元和延长半衰期部分(优选人IgG Fc变体)。该融合蛋白具有与重组(FVIII)类似的生物学活性及延长的体内活性半衰期,从而改善药代动力学和药效。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)