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1. (WO2018032505) CRYSTAL OF SULFATE OF POLYMYXIN B1, B2, OR MIXTURE THEREOF, AND MANUFACTURING METHOD OF SAME

Pub. No.:    WO/2018/032505    International Application No.:    PCT/CN2016/096061
Publication Date: Fri Feb 23 00:59:59 CET 2018 International Filing Date: Sat Aug 20 01:59:59 CEST 2016
IPC: C07K 7/62
A61K 38/12
A61P 31/04
Applicants: HUBEI RUIHAOANKE PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO., LTD.
湖北瑞昊安科医药科技发展有限公司
Inventors: LI, Xiaobing
李小兵
LUO, Fen
罗汾
WANG, Zengxia
王增霞
XU, Yanwei
许彦伟
LI, Changhong
李长洪
Title: CRYSTAL OF SULFATE OF POLYMYXIN B1, B2, OR MIXTURE THEREOF, AND MANUFACTURING METHOD OF SAME
Abstract:
Provided are an anhydrous crystal of a sulfate of polymyxin B1, B2, or mixture thereof, and manufacturing method of same. The manufacturing method comprises: using an organic solvent to generate a solid precipitate from a saturated solution of a sulfate of polymyxin B1, B2, or mixture thereof; and performing vacuum drying to obtain an anhydrous crystal of the sulfate of polymyxin B1, B2, or mixture thereof.