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1. (WO2018032359) ETHYL CARBAMATE HAPTEN COMBINATION, ARTIFICIAL ANTIGEN COMBINATION, AND METHOD FOR PREPARING SAME AND APPLICATION OF SAME
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/032359 International Application No.: PCT/CN2016/095543
Publication Date: 22.02.2018 International Filing Date: 16.08.2016
IPC:
C07C 269/04 (2006.01) ,C07C 271/22 (2006.01) ,C07C 271/28 (2006.01) ,C07K 14/77 (2006.01) ,C07K 14/795 (2006.01) ,C07K 16/44 (2006.01) ,G01N 33/577 (2006.01) ,G01N 33/543 (2006.01) ,G01N 33/531 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
269
Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
04
from amines with formation of carbamate groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
271
Derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
06
Esters of carbamic acids
08
having oxygen atoms of carbamate groups bound to acyclic carbon atoms
10
with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
22
to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
271
Derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
06
Esters of carbamic acids
08
having oxygen atoms of carbamate groups bound to acyclic carbon atoms
26
with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
28
to a carbon atom of a non-condensed six-membered aromatic ring
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
76
Albumins
77
Ovalbumin
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
795
Porphyrin- or corrin-ring-containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
44
against material not provided for elsewhere
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
577
involving monoclonal antibodies
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
543
with an insoluble carrier for immobilising immunochemicals
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
531
Production of immunochemical test materials
Applicants: SOUTH CHINA AGRICULTURAL UNIVERSITY[CN/CN]; SHAN, Xiangjie No.483 Five Mountain Road, Tianhe Guangzhou, Guangdong 510642, CN
Inventors: XU, Zhenlin; CN
SUN, Yuanming; CN
LUO, Lin; CN
YANG, Jinyi; CN
LEI, Hongtao; CN
SHEN, Yudong; CN
WANG, Hong; CN
Agent: YOGO PATENT & TRADE MARK AGENCY LIMITED COMPANY; Room3912, Blockb, Sinopec Tower Tiyu West Road, Tianhe Guangzhou, Guangdong 510620, CN
Priority Data:
Title (EN) ETHYL CARBAMATE HAPTEN COMBINATION, ARTIFICIAL ANTIGEN COMBINATION, AND METHOD FOR PREPARING SAME AND APPLICATION OF SAME
(FR) COMBINAISON D'HAPTÈNE DE CARBAMATE D'ÉTHYLE, COMBINAISON D'ANTIGÈNE ARTIFICIEL, SON PROCÉDÉ DE PRÉPARATION ET SON APPLICATION
(ZH) 一种氨基甲酸乙酯半抗原组合、人工抗原组合及其制备方法与应用
Abstract:
(EN) Provided are an ethyl carbamate hapten combination, artificial antigen combination, and method for preparing same and application of same. The ethyl carbamate artificial antigen combination has the molecular structure as shown in formula (III) and formula (IV); the potency of the antiserum obtained by said artificial antigen may reach 1.28×105, the minimum limit of detection is 0.16 mg/L, and the semi-inhibitory concentration is 1.19 mg/L; the specificity of the prepared antibody is high, sensitivity is high, and accuracy is high; it is possible to establish an immunoassay method for detecting ethyl carbamate; high-throughput screening for ethyl carbamate in food products is achieved, detection efficiency is improved, and detection costs are reduced.
(FR) L'invention concerne une combinaison d'haptène de carbamate d'éthyle, une combinaison d'antigène artificiel, son procédé de préparation et son application. La combinaison d'antigènes artificiels de carbamate d'éthyle a la structure moléculaire telle que représentée dans la formule (III) et la formule (IV); la puissance de l'antisérum obtenu par ledit antigène artificiel peut atteindre 1,28×105, la limite minimale de détection est de 0,16 mg/L, et la concentration semi-inhibitrice est de 1,19 mg/L; la spécificité de l'anticorps préparé est élevée, la sensibilité est élevée, et la précision est élevée; il est possible d'établir un procédé de dosage immunologique pour détecter le carbamate d'éthyle; un criblage à haut rendement pour le carbamate d'éthyle dans des produits alimentaires est obtenu, l'efficacité de détection est améliorée, et les coûts de détection sont réduits.
(ZH) 一种氨基甲酸乙酯人工抗原组合、人工抗原组合及其制备方法与应用。所述氨基甲酸乙酯人工抗原组合具有式(Ⅲ)和式(Ⅳ)所示分子结构,该人工抗原得到的抗血清的效价可达到1.28×10 5,最低检测限为0.16mg/L,半抑制浓度为1.19mg/L,制备的抗体特异性高,灵敏度高,准确度高,可建立检测氨基甲酸乙酯的免疫分析方法,实现对食品中氨基甲酸乙酯进行高通量筛查,提高检测效率,降低检测成本。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)