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1. (WO2018032272) METHOD FOR PREPARING OLIGOMERIC MANNURONIC DIACID
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/032272    International Application No.:    PCT/CN2016/095368
Publication Date: 22.02.2018 International Filing Date: 15.08.2016
IPC:
C07H 1/00 (2006.01), C07H 7/033 (2006.01)
Applicants: SHANGHAI GREEN VALLEY PHARMACEUTICAL CO., LTD. [CN/CN]; 421 Niudun Road, Zhang Jiang Hi-Tech Park, Pudong New Area Shanghai 201203 (CN)
Inventors: XIAO, Zhongping; (CN).
ZHANG, Zhenqing; (CN).
GENG, Meiyu; (CN).
DING, Jian; (CN)
Agent: KING & WOOD MALLESONS; 20th Floor, East Tower, World Financial Centre No. 1 Dongsanhuan Zhonglu Chaoyang District Beijing 100020 (CN)
Priority Data:
Title (EN) METHOD FOR PREPARING OLIGOMERIC MANNURONIC DIACID
(FR) PROCÉDÉ DE PRÉPARATION DE DIACIDE MANNURONIQUE OLIGOMÈRE
(ZH) 低聚甘露糖醛二酸的制备方法
Abstract: front page image
(EN)A novel method for preparing an important bioactive substance, oligomeric mannuronic diacid. The method uses oligomeric mannuronic acid as the starting material and obtains the target substance by means of steps of acid degradation and active hypobromous acid oxidation. The method for preparing the oligomeric mannuronic diacid in the present invention uses mild reaction conditions, has fewer side reactions, does not require further purification, can reach a yield of 90% or more, even 95% or more, and is suitable for production in an on-line continuous reaction device, and an automated control is easily achieved for reaction process thereof.
(FR)L'invention concerne un nouveau procédé de préparation d'une substance bioactive importante, d'un diacide mannuronique oligomère. Le procédé utilise de l'acide mannuronique oligomère en tant que matériau de départ et obtient la substance cible au moyen d'étapes de dégradation d'acide et d'oxydation d'acide hypobromeux active. Le procédé de préparation du diacide mannuronique oligomère dans la présente invention utilise des conditions de réaction modérées, présente moins de réactions secondaires, ne nécessite pas d'autres purification, peut atteindre un rendement de 90 % ou plus, même 95 % ou plus, et est approprié pour la production dans un dispositif de réaction continue en ligne, et une commande automatisée est facilement obtenue pour un processus de réaction de celle-ci.
(ZH)一种重要的生物活性物质低聚甘露糖醛二酸的新制备方法,该方法使用低聚甘露糖醛酸作为起始原料,通过酸降解、活性次溴酸氧化步骤得到目标物质。本发明的低聚甘露糖醛二酸的制备方法采用了温和的反应条件,副反应少,不需要进一步纯化,收率可达90%以上,甚至达95%以上,并且适合用在线连续反应装置生产,反应过程易于实现自动化控制。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)