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1. (WO2018032088) REGULATION OF TUMOR-ASSOCIATED T CELLS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/032088    International Application No.:    PCT/CA2017/000192
Publication Date: 22.02.2018 International Filing Date: 17.08.2017
IPC:
A61P 35/00 (2006.01)
Applicants: UNIVERSITY HEALTH NETWORK [CA/CA]; 190 Elizabeth Street R. Fraser Elliott Building Room 1S-417 Toronto, Ontario M5G 2C4 (CA)
Inventors: NGUYEN, Thuy-Linh; (CA).
OHASHI, Pamela S.; (CA).
CROME, Sarah; (CA)
Agent: CHIU, Jung-Kay; Norton Rose Fuibright Canada LLP /S.E.N.C.R.L., s.r.l. 1 Place Ville Marie Suite 2500 Montreal, Quebec, H3B 1R1 (CA)
Priority Data:
62/375,970 17.08.2016 US
Title (EN) REGULATION OF TUMOR-ASSOCIATED T CELLS
(FR) RÉGULATION DE LYMPHOCYTES T ASSOCIÉS À UNE TUMEUR
Abstract: front page image
(EN)There is described herein methods for improving tumor infiltrating lymphocyte (TIL) therapy by limiting the effect of innate lymphoid cells (ILCs) thereon. For example, in an aspect, there is provided a method of treating cancer in a patient in need thereof, comprising inhibiting the suppressive effect of CD56+CD3- innate lymphoid cells (ILCs) on tumor infiltrating lymphocyte (TIL) propagation or expansion.
(FR)La présente invention concerne des méthodes permettant d'améliorer une thérapie des lymphocytes infiltrant les tumeurs (TIL) en limitant l'effet des cellules lymphoïdes innées (ILC) sur ceux-ci. Par exemple, selon un aspect, l'invention concerne une méthode de traitement du cancer chez un patient ayant besoin de celui-ci, consistant à inhiber l'effet suppresseur des cellules lymphoïdes innées CD56+CD3- (ILC) sur la propagation ou l'expansion des lymphocytes infiltrant les tumeurs (TIL).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)