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1. (WO2018031987) PROTEIN KINASE REGULATORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/031987 International Application No.: PCT/US2017/046715
Publication Date: 15.02.2018 International Filing Date: 14.08.2017
IPC:
A61K 31/519 (2006.01) ,C07D 471/14 (2006.01) ,A61P 35/00 (2006.01)
Applicants: IWANOWICZ, Edwin, J.[US/US]; US
NANJING GATOR MEDITECH COMPANY, LTD.[CN/CN]; No 3 Gutan Road, Suite 6 Gaochun, Nanjin, 210000, CN
Inventors: IWANOWICZ, Edwin, J.; US
Agent: KOHN, David, M.; US
Priority Data:
62/374,39912.08.2016US
Title (EN) PROTEIN KINASE REGULATORS
(FR) RÉGULATEURS DE PROTÉINE KINASES
Abstract: front page image
(EN) The present invention provides, in part, novel compounds and pharmaceutically acceptable salts capable of modulating the activity of kinases, including Akt, ERK and MEK. Such modulation affects biological functions, for example, by inhibiting cell proliferation and/or inducing apoptosis. Also provided are pharmaceutical compositions and medicaments, comprising the compounds or salts of the invention, alone or in combination with other therapeutic agents or palliative agents.
(FR) La présente invention concerne, en partie, de nouveaux composés et des sels pharmaceutiquement acceptables, permettant de moduler l'activité de kinases, comprenant Akt, ERK et MEK. Une telle modulation influence des fonctions biologiques, par exemple en inhibant la prolifération cellulaire et/ou en induisant l'apoptose. L'invention concerne également des compositions pharmaceutiques et des médicaments, comprenant les composés ou les sels de l'invention, seuls ou en association avec d'autres agents thérapeutiques ou agents palliatifs.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)