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1. (WO2018031690) DRUG CONJUGATES WITH SELF-STABILIZING LINKERS HAVING IMPROVED PHYSIOCHEMICAL PROPERTIES

Pub. No.:    WO/2018/031690    International Application No.:    PCT/US2017/046157
Publication Date: Fri Feb 16 00:59:59 CET 2018 International Filing Date: Thu Aug 10 01:59:59 CEST 2017
IPC: A61K 39/00
C07K 5/062
C07D 207/36
Applicants: SEATTLE GENETICS, INC.
Inventors: MOQUIST, Philip
Title: DRUG CONJUGATES WITH SELF-STABILIZING LINKERS HAVING IMPROVED PHYSIOCHEMICAL PROPERTIES
Abstract:
Compounds and compositions are disclosed in which a Drug Unit is linked to a targeting Ligand Unit through a self-stabilizing Linker Unit from which a drug compound or active drug moiety is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as cancer or an autoimmune disease using the compounds and compositions of the invention are also disclosed.