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1. (WO2018031662) PYRROLOBENZODIAZEPINE PRODRUGS AND ANTIBODY CONJUGATES THEREOF
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Pub. No.: WO/2018/031662 International Application No.: PCT/US2017/046102
Publication Date: 15.02.2018 International Filing Date: 09.08.2017
IPC:
A61K 47/68 (2017.01) ,A61P 35/00 (2006.01)
[IPC code unknown for A61K 47/68]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, CA 94080-4990, US
Inventors:
DRAGOVICH, Peter; US
PEI, Zhonghua; US
PILLOW, Thomas; US
SADOWSKY, Jack; US
VERMA, Vishal; US
ZHANG, Donglu; US
Agent:
ANDRUS, Alex; US
HARRIS, Robert J.; US
VIKSNINS, Ann S.; US
MALEN, Peter L.; US
KRUGER, Katherine A.D.; US
MICKELSON, John W.; US
PADYS, Dan J.; US
KLIMA SILMBERG, Catherine I.; US
Priority Data:
62/373,74011.08.2016US
Title (EN) PYRROLOBENZODIAZEPINE PRODRUGS AND ANTIBODY CONJUGATES THEREOF
(FR) PROMÉDICAMENTS DE PYRROLOBENZODIAZÉPINE ET CONJUGUÉS D'ANTICORPS DE CEUX-CI
Abstract:
(EN) The invention relates generally to pyrrolobenzodiazepine monomer and dimer prodrugs having a glutathione-activated disulfide prodrug moiety, a DT-diaphorase-activated quinone prodrug moiety or a reactive oxygen species-activated aryl boronic acid or aryl boronic ester prodrug moiety. The invention further relates to pyrrolobenzodiazepine prodrug dimer-antibody conjugates.
(FR) L'invention concerne généralement des promédicaments monomères et dimères de pyrrolobenzodiazépine comportant une fraction de promédicament disulfure activée par glutathion, une fraction de promédicament quinone activée par DT-diaphorase ou une fraction de promédicament sous forme d'acide boronique d'aryle ou d'ester boronique d'aryle activée par espèce d'oxygène. L'invention concerne en outre des conjugués dimères-anticorps de promédicament de pyrrolobenzodiazépine.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)