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1. (WO2018031662) PYRROLOBENZODIAZEPINE PRODRUGS AND ANTIBODY CONJUGATES THEREOF

Pub. No.:    WO/2018/031662    International Application No.:    PCT/US2017/046102
Publication Date: Fri Feb 16 00:59:59 CET 2018 International Filing Date: Thu Aug 10 01:59:59 CEST 2017
IPC: A61K 47/68
A61P 35/00
Applicants: GENENTECH, INC.
Inventors: DRAGOVICH, Peter
PEI, Zhonghua
PILLOW, Thomas
SADOWSKY, Jack
VERMA, Vishal
ZHANG, Donglu
Title: PYRROLOBENZODIAZEPINE PRODRUGS AND ANTIBODY CONJUGATES THEREOF
Abstract:
The invention relates generally to pyrrolobenzodiazepine monomer and dimer prodrugs having a glutathione-activated disulfide prodrug moiety, a DT-diaphorase-activated quinone prodrug moiety or a reactive oxygen species-activated aryl boronic acid or aryl boronic ester prodrug moiety. The invention further relates to pyrrolobenzodiazepine prodrug dimer-antibody conjugates.