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1. (WO2018031636) METHODS OF DETECTING MLH1 METHYLATION
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Pub. No.: WO/2018/031636 International Application No.: PCT/US2017/046070
Publication Date: 15.02.2018 International Filing Date: 09.08.2017
IPC:
C12Q 1/68 (2006.01) ,C12N 9/16 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
16
acting on ester bonds (3.1)
Applicants:
QUEST DIAGNOSTICS INVESTMENTS LLC [US/US]; 500 Plaza Drive Secaucus, New Jersey 07094, US
Inventors:
QU, Kevin; US
HANTASH, Feras; US
DONAHUE, Amber; US
Agent:
SCHORR, Kristel; US
LAW, Glenn; US
AGARWAL, Pavan K.; US
BECK, George C.; US
BERKOWITZ, Benjamin A.; US
BRINCKERHOFF, Courtenay C.; US
CHESLOCK, Andrew R.; US
FELDHAUS, John J.; US
KAMINSKI, Michael D.; US
MAEBIUS, Stephen B.; US
QUILLIN, George E.; US
RAWLINS, Andrew E.; US
SIMKIN, Michele M.; US
TALAPATRA, Sunit; US
VILLACORTA, Gilberto M.; US
YAN, Tianran; US
Priority Data:
62/373,06010.08.2016US
Title (EN) METHODS OF DETECTING MLH1 METHYLATION
(FR) MÉTHODES DE DÉTECTION DE LA MÉTHYLATION DE MLH1
Abstract:
(EN) The present technology relates to methods for excluding Lynch syndrome as a possible diagnosis in patients suffering from colorectal cancers or endometrial cancers. These methods are based on detecting the methylation status of the MLH1 promoter 'C, region in colorectal and endometrial cancer patients using an improved and highly sensitive methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) assay.
(FR) La présente invention se rapporte à des procédés permettant d'exclure le syndrome de Lynch des diagnostics possibles chez des patients souffrant de cancers colorectaux ou de cancers de l'endomètre. Ces procédés sont basés sur la détection de l'état de méthylation de la région 'C, du promoteur de MLH1 chez des patients atteints d'un cancer colorectal ou d'un cancer de l'endomètre au moyen d'une analyse par amplification de sonde dépendant d'une ligature multiplex spécifique à la méthylation (MS-MLPA) perfectionnée et très sensible.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)