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1. (WO2018031445) COMBINATION OF T-CELL CHECKPOINT INHIBITORS WITH INHIBITORS OF E-SELECTIN OR CXCR4, OR WITH HETEROBIFUNCTIONAL INHIBITORS OF BOTH E-SELECTIN AND CXCR4
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Pub. No.: WO/2018/031445 International Application No.: PCT/US2017/045690
Publication Date: 15.02.2018 International Filing Date: 07.08.2017
IPC:
C07K 16/28 (2006.01) ,A61K 31/7034 (2006.01) ,A61K 39/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7028
Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7034
attached to a carbocyclic compound, e.g. phloridzin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
Applicants: GLYCOMIMETICS, INC.[US/US]; 9708 Medical Center Drive Rockville, Maryland 20850, US
Inventors: MAGNANI, John L.; US
FOGLER, William E.; US
Agent: CHAPMAN, Ernest F.; US
WEINGARTEN, M. David; US
MARKS, Jessica L.A.; US
MACALPINE, Jill K.; US
VAN HORN, Charles; US
Priority Data:
62/372,11608.08.2016US
62/417,04503.11.2016US
62/418,72207.11.2016US
Title (EN) COMBINATION OF T-CELL CHECKPOINT INHIBITORS WITH INHIBITORS OF E-SELECTIN OR CXCR4, OR WITH HETEROBIFUNCTIONAL INHIBITORS OF BOTH E-SELECTIN AND CXCR4
(FR) COMBINAISON D'INHIBITEURS DES POINTS DE CONTRÔLE DES LYMPHOCYTES T AVEC DES INHIBITEURS DE E-SÉLECTINE OU DE CXCR4, OU AVEC DES INHIBITEURS HÉTÉROBIFONCTIONNELS DE E-SÉLECTINE ET DE CXCR4
Abstract:
(EN) Compositions and methods for the treatment of diseases, disorders, and/or conditions associated with the increased regulatory T lymphocyte cell (Treg cell) function, comprising the administration of T-cell checkpoint inhibitors in combination with E-selectin inhibitors, CXCR4 receptor inhibitors, and/or heterobifunctional inhibitors that comprise at least one E-selectin inhibitor linked to at least one CXCR4 receptor inhibitor, are disclosed.
(FR) L'invention concerne des compositions et des méthodes pour le traitement de maladies, de troubles et/ou d'affections associés à la fonction renforcée des lymphocytes T régulateurs (Treg), comprenant l'administration d'inhibiteurs des points de contrôle des lymphocytes T en combinaison avec des inhibiteurs de E-sélectine, des inhibiteurs des récepteurs CXCR4 et/ou des inhibiteurs hétérobifonctionnels qui comprennent au moins un inhibiteur de E-sélectine lié à au moins un inhibiteur des récepteurs CXCR4.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)