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1. (WO2018030874) MANIPULATED IMMUNOREGULATORY ELEMENT AND IMMUNITY ALTERED THEREBY

Pub. No.:    WO/2018/030874    International Application No.:    PCT/KR2017/008835
Publication Date: Fri Feb 16 00:59:59 CET 2018 International Filing Date: Tue Aug 15 01:59:59 CEST 2017
IPC: C12N 15/63
C12N 15/85
C12N 9/22
C12N 5/078
A61K 35/14
Applicants: TOOLGEN INCORPORATED
주식회사 툴젠
Inventors: KIM, Seok Joong
김석중
KIM, Yoon-Young
김윤영
YU, Ho-Sung
유호성
JUNG, In-Young
정인영
LEE, Jung Min
이정민
Title: MANIPULATED IMMUNOREGULATORY ELEMENT AND IMMUNITY ALTERED THEREBY
Abstract:
The present invention relates to an artificially manipulated immune system having an improved immune effect. More particularly, the present invention relates to an immune system having functions artificially altered which comprises artificially manipulated immunoregulatory elements and cells containing the same. Contemplated according to a particular embodiment is an immune system comprising artificially manipulated immunoregulatory genes such as PD-1, CTLA-4, A20, DGKα, DGKζ, FAS, EGR2, PPP2R2D, PSGL-1, KDM6A, and TET2, and/or expression products thereof.