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1. (WO2018030789) PEPTIDE NUCLEIC ACID COMPLEX HAVING IMPROVED CELL PERMEABILITY AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/030789    International Application No.:    PCT/KR2017/008636
Publication Date: 15.02.2018 International Filing Date: 09.08.2017
IPC:
C12N 15/113 (2010.01), C12Q 1/68 (2006.01), C07K 14/00 (2006.01), A61K 31/7088 (2006.01), A61K 47/54 (2017.01)
Applicants: SEASUNBIO MATERIALS [KR/KR]; N517 11-3, Techno 1-ro Yuseong-gu Daejeon 34015 (KR)
Inventors: JEO, Goonho; (KR).
KIM, Hye Joo; (KR).
YU, Ji-Yeon; (KR).
BATOCHIR, Chinbayar; (KR).
HUR, Deokhwe; (KR).
PARK, Hee Kyung; (KR)
Agent: LEE, Cheo Young; (KR).
CHANG, Je Hwan; (KR)
Priority Data:
10-2016-0101374 09.08.2016 KR
Title (EN) PEPTIDE NUCLEIC ACID COMPLEX HAVING IMPROVED CELL PERMEABILITY AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
(FR) COMPLEXE D’ACIDE NUCLÉIQUE PEPTIDIQUE PRÉSENTANT UNE PERMÉABILITÉ CELLULAIRE AMÉLIORÉE ET COMPOSITION PHARMACEUTIQUE COMPRENANT CE DERNIER
(KO) 세포투과성이 향상된 펩티드 핵산 복합체 및 이를 포함하는 약학적 조성물
Abstract: front page image
(EN)The present invention relates to a novel structure of nucleic acid complex in which bioactive nucleic acid can be introduced into cells, to a composition comprising the nucleic acid complex for treatment and diagnosis of diseases, and to a method for regulating the expression of a target gene using the same and, more specifically, to a nucleic acid complex in which a bioactive nucleic acid is complementarily combined with a carrier peptide nucleic acid modified to have a positive charge overall, to a composition comprising the nucleic acid complex for treatment and diagnosis of diseases, and to a method for regulating the expression of a target gene using the same.
(FR)La présente invention décrit une nouvelle structure de complexe d’acide nucléique dans laquelle un acide nucléique bioactif peut être introduit dans les cellules, une composition comprenant le complexe d’acide nucléique pour le traitement et le diagnostic des maladies, et un procédé de régulation de l’expression d’un gène cible l’utilisant et, plus spécifiquement, un complexe d’acide nucléique dans lequel un acide nucléique bioactif est complémentairement associé à un acide nucléique peptidique support modifié pour avoir une charge positive dans son ensemble, une composition comprenant le complexe d’acide nucléique destiné au traitement et au diagnostic de maladies, et un procédé de régulation de l’expression d’un gène cible l’utilisant.
(KO)본 발명은 생활성 핵산을 세포내에 도입할 수 있는 새로운 구조의 핵산 복합체, 이를 포함하는 질병의 치료 및 진단용 조성물 및 이를 이용한 표적 유전자의 발현 조절 방법에 관한 것으로, 더욱 자세하게는, 생활성 핵산과 전체적으로 양전하를 가지도록 변형된 캐리어 펩티드 핵산(Carrier Peptide Nucleic Acid)이 상보적으로 결합된 핵산 복합체 이를 포함하는 질병의 치료 및 진단용 조성물 및 이를 이용한 표적 유전자의 발현 조절 방법에 관한 것이다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)