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1. (WO2018030732) NANOVESICLES DERIVED FROM GENUS BACILLUS BACTERIA AND USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/030732    International Application No.:    PCT/KR2017/008497
Publication Date: 15.02.2018 International Filing Date: 07.08.2017
IPC:
A61K 35/742, A23L 33/135 (2016.01), A61K 8/99 (2006.01), A61K 9/00 (2006.01), A61Q 19/00 (2006.01)
Applicants: MD HEALTHCARE INC. [KR/KR]; (Sangam-dong,Woori Technology Bldg.) #1303, 9, World Cup buk-ro 56-gil, Mapo-gu, Seoul 03923 (KR)
Inventors: KIM, Yoon-Keun; (KR)
Agent: LEE, Myoung-Jin; (KR)
Priority Data:
10-2016-0102650 12.08.2016 KR
10-2017-0098860 04.08.2017 KR
Title (EN) NANOVESICLES DERIVED FROM GENUS BACILLUS BACTERIA AND USE THEREOF
(FR) NANOVÉSICULES DÉRIVÉES DE BACTÉRIES DU GENRE BACILLUS ET LEUR UTILISATION
(KO) 바실러스 속 세균 유래 나노소포 및 이의 용도
Abstract: front page image
(EN)The present invention relates to vesicles derived from the genus Bacillus bacteria and a use thereof. The present inventors have confirmed that the vesicles are significantly reduced in samples of patients with cancers, such as liver cancer, bladder cancer, breast cancer, and ovarian cancer; inflammatory diseases, such as asthma and atopic dermatitis; or metabolic diseases, such as diabetes and cirrhosis, compared with normal persons, and the vesicles inhibited the secretion of inflammatory mediators by pathogenic vesicles, such as E. coli-derived vesicles, which are causative factors of inflammatory diseases, diabetes, and the like. Therefore, the vesicles derived from the genus Bacillus bacteria according to the present invention can be advantageously used for the purpose of developing a diagnostic method for cancer, inflammatory diseases, and metabolic diseases, and a preventive or therapeutic composition therefor.
(FR)La présente invention concerne des vésicules dérivées de bactéries du genre Bacillus et leur utilisation. Les présents inventeurs ont confirmé que les vésicules présentent un niveau significativement réduit dans des prélèvements de patients affectés de cancers, tels que le cancer du foie, le cancer de la vessie, le cancer du sein, et le cancer de l’ovaire ; les maladies inflammatoires, telles que l’asthme et la dermatite atopique ; ou les maladies métaboliques, telles que le diabète et la cirrhose, comparés aux personnes normales, et les vésicules inhibaient la sécrétion des médiateurs inflammatoires par les vésicules pathogènes, telles que les vésicules dérivées d’E. coli, qui sont des facteurs responsables des maladies inflammatoires, du diabète, et similaires. Par conséquent, les vésicules dérivées de bactéries du genre Bacillus selon la présente invention peuvent avantageusement être utilisées aux fins de développer un procédé de diagnostic du cancer, de maladies inflammatoires, et de maladies métaboliques, et une composition préventive ou thérapeutique associée.
(KO)본 발명은 바실러스 속 세균 유래 소포 및 이의 용도에 관한 것이다. 본 발명자들은 정상인에 비하여 간암, 방광암, 유방암, 난소암 등의 암환자, 천식, 아토피피부염 등의 염증질환, 또는 당뇨병, 간경화증 등의 대사질환 환자의 샘플에 상기 소포가 유의하게 감소되어 있고, 상기 소포는 염증질환, 당뇨병 등의 원인인자인 대장균 유래 소포와 같은 병원성 소포에 의한 염증매개체 분비를 억제함을 확인하였는바, 본 발명에 따른 바실러스 속 세균 유래 소포는 암, 염증질환, 및 대사질환의 진단방법, 및 예방 또는 치료용 조성물을 개발하기 위한 목적으로 유용하게 이용될 수 있을 것이다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)