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1. (WO2018030451) THERAPEUTIC AGENT FOR ADHESION, METHOD FOR TREATING ADHESION, POSTOPERATIVE ADHESION MARKER, AND METHOD FOR EXAMINING SUSCEPTIBILITY TO POSTOPERATIVE ADHESION

Pub. No.:    WO/2018/030451    International Application No.:    PCT/JP2017/028869
Publication Date: Fri Feb 16 00:59:59 CET 2018 International Filing Date: Thu Aug 10 01:59:59 CEST 2017
IPC: A61K 45/00
A61K 31/7088
A61K 48/00
A61P 43/00
C12N 15/113
Applicants: EDUCATIONAL FOUNDATION OF OSAKA MEDICAL AND PHARMACEUTICAL UNIVERSITY
学校法人大阪医科薬科大学
AQUA THERAPEUTICS CO., LTD.
株式会社アクアセラピューティクス
Inventors: TAKAI Shinji
高井 真司
KIN Tokunan
金 徳男
YOSHIKAWA Kazunori
吉川 寿徳
TAKAO Kazumasa
高尾 和正
YOSHINO Masafumi
吉野 雅文
Title: THERAPEUTIC AGENT FOR ADHESION, METHOD FOR TREATING ADHESION, POSTOPERATIVE ADHESION MARKER, AND METHOD FOR EXAMINING SUSCEPTIBILITY TO POSTOPERATIVE ADHESION
Abstract:
The present invention provides a therapeutic agent for an adhesion, a method for treating an adhesion, a postoperative adhesion marker and a method for testing for susceptibility to a postoperative adhesion, each of which can be applied to an adhesion occurring, for example, during an operation with an endoscope or the like or in an endogenous disease. The therapeutic agent for an adhesion according to the present invention is characterized by containing an expression-inhibiting substance capable of inhibiting the expression of periostin and/or a binding substance capable of binding to periostin. In the therapeutic agent for an adhesion according to the present invention, the expression-inhibiting substance comprises at least one substance selected from the group consisting of a substance capable of inhibiting the expression of mRNA for a periostin gene, a substance capable of cleaving the expressed mRNA and a substance capable of inhibiting the translation of a protein from the expressed mRNA.