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1. (WO2018029618) ANTIBACTERIAL GUANIDINE DERIVATIVES
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Pub. No.: WO/2018/029618 International Application No.: PCT/IB2017/054870
Publication Date: 15.02.2018 International Filing Date: 09.08.2017
IPC:
C07C 279/18 (2006.01) ,A61K 31/155 (2006.01) ,A61P 31/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
279
Derivatives of guanidine, i.e. compounds containing the group the singly-bound nitrogen atoms not being part of nitro or nitroso groups
18
having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
155
Amidines (), e.g. guanidine (H2N-C(NH)-NH2), isourea (HNC(OH)NH2), isothiourea (HNC(SH)-NH2)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
Applicants:
BOSCH, María A. [IT/AR]; AR
CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET) [AR/AR]; Godoy Cruz 2290 - Piso 10 Ciudad Autónoma de Buenos Aires, C1425FQB, AR
UNIVERSIDAD NACIONAL DE LA PLATA (UNLP) [AR/AR]; Calle 7 Nro. 776 La Plata - Pcia. de Buenos Aires, 1900, AR
QUAID-I-AZAM UNIVERSITY [PK/PK]; QUAID-I-AZAM UNIVERSITY ISLAMABAD, 45320, PK
Inventors:
BOSCH, María A.; AR
ERBEN, Mauricio F.; AR
LAMBERTI, Yanina A.; AR
SAEED BHATTI, Aamer; PK
Priority Data:
2016010246511.08.2016AR
Title (EN) ANTIBACTERIAL GUANIDINE DERIVATIVES
(FR) DÉRIVÉS DE GUANIDINE ANTIBACTÉRIENS
Abstract:
(EN) An antibacterial compound of formula I, wherein X is selected from fluoro or bromo, effective against Gram negative and Gram positive bacteria, and in particular against non-fermenting multiresistant bacteria affecting patients suffering from cystic fibrosis and which are responsible of severe hospital-acquired infections in immunodepressed patients; its preparation process and pharmaceutical composition comprising said compound. (Formula I)
(FR) L'invention concerne un composé antibactérien de formule I, dans laquelle X est choisi parmi fluoro ou bromo, efficace contre les bactéries Gram négatif et Gram positif, et en particulier contre des bactéries multirésistantes non fermentantes affectant des patients souffrant de fibrose kystique et qui sont responsables d'infections graves acquises à l'hôpital chez des patients immunodéprimés; son procédé de préparation et une composition pharmaceutique comprenant ledit composé. (Formule I)
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)