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1. (WO2018029517) ANDROGEN RECEPTOR ANTISENSE OLIGONUCLEOTIDES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/029517 International Application No.: PCT/IB2017/000697
Publication Date: 15.02.2018 International Filing Date: 24.05.2017
IPC:
C07K 14/00 (2006.01) ,A61K 38/00 (2006.01)
Applicants: OLIPASS CORPORATION[KR/KR]; 20th Floor, Ace Dongbaek Tower 16 Beon-gil, 16-7 Dongbaek Jungang-ro Giheung-gu, Yongin-si, Gyeonggi-do 17015, KR
Inventors: CHUNG, Shin; KR
JUNG, Daram; KR
CHO, Bongjun; KR
JANG, Kangwon; KR
YOON, Heungsik; KR
Priority Data:
62/372,03508.08.2016US
Title (EN) ANDROGEN RECEPTOR ANTISENSE OLIGONUCLEOTIDES
(FR) OLIGONUCLÉOTIDES ANTISENS DU RÉCEPTEUR DES ANDROGÈNES
Abstract: front page image
(EN) Provided are peptide nucleic acid derivatives targeting the 5' splice site of "exon 5" within the human androgen receptor pre-mRNA. The peptide nucleic acid derivatives potently induce splice variants of the androgen receptor mRNA in cells, and are useful to safely treat dermatological indications or conditions involving androgenic activity upon topical administration.
(FR) L'invention concerne des dérivés d'acides nucléiques peptidiques ciblant le site d'épissage 5' de "l'exon 5" dans le pre-ARNm du récepteur des androgènes humains. Les dérivés d'acide nucléique peptidique induisent puissamment des variants d'épissage de l'ARNm du récepteur d'androgène dans des cellules, et sont utiles pour traiter en toute sécurité des indications ou des états dermatologiques impliquant une activité androgène lors de l'administration topique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)