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Machine translation
1. (WO2018029367) COMBINATION THERAPY FOR CANCER
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/029367 International Application No.: PCT/EP2017/070513
Publication Date: 15.02.2018 International Filing Date: 11.08.2017
IPC:
C07K 16/28 (2006.01) ,A61K 38/17 (2006.01) ,C07K 14/71 (2006.01) ,A61P 35/00 (2006.01) ,A61K 31/282 (2006.01) ,A61K 31/513 (2006.01) ,A61K 39/395 (2006.01)
Applicants: MERCK PATENT GMBH[DE/DE]; Frankfurter Strasse 250 64293 Darmstadt, DE
Inventors: LO, Kin-Ming; US
LAN, Yan; US
Agent: SUTCLIFFE, Nicholas; GB
ADDISS, John; GB
ANDREWS, Robert; GB
BAILEY, Sam; GB
BRASNETT, Adrian; GB
BREARLEY, Sarah; GB
BURNS, Alex; GB
CARLISLE, Julie; GB
CARTER, Stephen; GB
CASLEY, Christopher; GB
CLEGG, Richard; GB
CRIPPS, Joanna; GB
DALE, Elizabeth; GB
DENISON, Christopher; GB
DUNNE, Paul; GB
FORREST, Graham; GB
FURNIVAL, Tom; GB
GILL, Stephen; GB
GRAHAM, Emma; GB
GREEN, Katherine; GB
GREGORY, Adam; GB
HARRISON, Susan; GB
HAYES, Emily; GB
HODSDON, Stephen; GB
JOHNSON, Richard; GB
JONES, Rachel; GB
KEIRSTEAD, Tanis; GB
KIDDLE, Simon; GB
KREMER, Simon; GB
LEACH, James; GB
LENTHALL, Joseph; GB
LYONS, June; GB
MACIVER, Eleanor; GB
MCGUINN, Callum; GB
MOORE, Graeme; GB
NAYLOR, Matthew; GB
OXLEY, Rachel; GB
PARRY, Simon; GB
SALISBURY, Frances; GB
SMITH, Matthew; GB
STONER, Patrick; GB
THORNTON, Dan; GB
TOLLERVEY, Rebecca; GB
WALTON, Seán; GB
WARD, Eliot; GB
WATSON, Robert; GB
WEBSTER, Jeremy; GB
WESCOTT, Rhiannon; GB
WILLS, Jonathan; GB
WYTENBURG, Wilhelmus; GB
Priority Data:
62/374,62112.08.2016US
Title (EN) COMBINATION THERAPY FOR CANCER
(FR) POLYTHÉRAPIE CONTRE LE CANCER
Abstract:
(EN) This invention relates generally to a combination therapy for the treatment of cancer, particularly to a combination of (i) a bifunctional molecule comprising a TGFßRII or fragment thereof capable of binding TGFß and an antibody, or antigen binding fragment thereof, that binds to an immune checkpoint protein, such as Programmed Death Ligand 1 (PD-L1) and (ii) at least one additional anti-cancer therapeutic agent.
(FR) L'invention concerne de manière générale une polythérapie pour le traitement du cancer, en particulier une combinaison de (i) une molécule bifonctionnelle comprenant un TGFßRII ou un fragment de celui-ci capable de se lier à TGFß et un anticorps, ou un fragment de liaison à l'antigène de celui-ci, qui se lie à une protéine de point de contrôle immunitaire, telle que le Ligand de Mort Programmée 1 (PD-L1) et (ii) au moins un agent thérapeutique anticancéreux supplémentaire.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)