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1. (WO2018029347) PRODUCTION OF BITTER PRINCIPLE DERIVATIVES

Pub. No.:    WO/2018/029347    International Application No.:    PCT/EP2017/070450
Publication Date: Fri Feb 16 00:59:59 CET 2018 International Filing Date: Sat Aug 12 01:59:59 CEST 2017
IPC: A61K 49/00
C07C 233/07
C07K 17/06
Applicants: JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURG
Inventors: WYRWA, Ralf
RODE, Claudia
SEEMANN, Thomas
MEINEL, Lorenz
RITZER, Jennifer
SCHNABELRAUCH, Matthias
Title: PRODUCTION OF BITTER PRINCIPLE DERIVATIVES
Abstract:
1. Synthesis of bitter principle derivatives based on the denatonium structure according to formula (1). 2.1. The aim of the invention is to introduce couplable carboxylic acid functionalities into the denatonium structure by means of simple synthesis. 2.2. According to the invention, lidocaine derivatives are reacted with carboxylated benzyl halogenides. 2.3. The carboxylated denatonium derivatives are particularly applicable in medicine, biology and medical engineering, and in the cosmetic, pharmaceutical, chemical and food industries.