Search International and National Patent Collections

1. (WO2018029292) METHOD FOR TREATING GLIOMA

Pub. No.:    WO/2018/029292    International Application No.:    PCT/EP2017/070288
Publication Date: Fri Feb 16 00:59:59 CET 2018 International Filing Date: Fri Aug 11 01:59:59 CEST 2017
IPC: A61K 31/704
A61K 31/555
A61K 31/519
A61P 35/00
A61K 45/06
A61K 36/77
Applicants: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
UNIVERSITÉ DE NANTES
UNIVERSITÉ D'ANGERS
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
Inventors: GAVARD, Julie
HARFORD-WRIGHT, Elisabeth
BIDERE, Nicolas
Title: METHOD FOR TREATING GLIOMA
Abstract:
The present invention relates to the treatment of glioma. Considering the potential of anti-GIC therapies to advance GBM treatment, the inventors employed a chemical screen of currently FDA- and EM A- approved small molecules in order to identify a selective inhibitor of GIC (the four genetic subtypes of GBM) expansion with known bio-safety in humans. The cytotoxic effect of the compounds was initially evaluated in two patient-derived GIC growing as spheres and identified β-escin, a mixture of triterpenoid saponins isolated from the seeds of horse chestnuts. They demonstrated a specific effect of β-escin on induction of apoptosis and modulation of sternness properties of nine individual GIC, indicating the potential of β-escin as a selective and potent inhibitor of GIC. Thus the invention relate to an escin family compound (and particularly β-escin) for use in the treatment of glioma.