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1. (WO2018029256) MODULATION OF IFI16 AND STING ACTIVITY

Pub. No.:    WO/2018/029256    International Application No.:    PCT/EP2017/070208
Publication Date: Fri Feb 16 00:59:59 CET 2018 International Filing Date: Thu Aug 10 01:59:59 CEST 2017
IPC: C07K 14/52
A61K 38/17
Applicants: AARHUS UNIVERSITET
Inventors: JAKOBSEN, ROELSGAARD, Martin
PALUDAN, RIIS, Søren
JØNSSON, LISAGER, Kasper
Title: MODULATION OF IFI16 AND STING ACTIVITY
Abstract:
Compounds capable of mimicking the pyrin-domain of IF116 is provided together with compounds capable of binding to the pyrin-domain of IFl16 or a fragment thereof as well as their uses in medicine. Specifically, the compounds are provided for use in the treatment of disorders associated with STING activity, including cancer and immuno- deficient or auto-immune disorders.