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1. (WO2018028560) APPLICATION OF PHOSPHODIESTERASE 4 INHIBITOR ZL-N-91 IN PREPARATION OF MEDICAMENT FOR TREATING PROSTATE CANCER PROLIFERATION AND METASTASIS
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Pub. No.: WO/2018/028560 International Application No.: PCT/CN2017/096399
Publication Date: 15.02.2018 International Filing Date: 08.08.2017
IPC:
A61K 31/341 (2006.01) ,A61P 35/00 (2006.01) ,A61P 35/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
34
having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
341
not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
04
specific for metastasis
Applicants: GUANGZHOU SINOGEN BIOMEDICAL TECHNOLOGY, LTD[CN/CN]; No. 427, A4 Building, No. 3, Science Road Science City, High-tech Development Zone Guangzhou, Guangdong 510663, CN
Inventors: ZHAO, Allan zijian; CN
GONG, Sijia; CN
LIN, Yan; CN
LI, Fanghong; CN
LI, Xiaoxi; CN
ZHOU, Sujin; CN
ZHAO, Zhenggang; CN
Agent: NANJING SUGAO PATENT AND TRADEMARK FIRM (ORDINARY PARTNERSHIP); Room 1912, Longtaiguoji Mansion, No.198, East Zhongshan Street, Baixia District Nanjing, Jiangsu 210005, CN
Priority Data:
201610652824.610.08.2016CN
Title (EN) APPLICATION OF PHOSPHODIESTERASE 4 INHIBITOR ZL-N-91 IN PREPARATION OF MEDICAMENT FOR TREATING PROSTATE CANCER PROLIFERATION AND METASTASIS
(FR) APPLICATION DE ZL-N-91, INHIBITEUR DE PHOSPHODIESTÉRASE 4, DANS LA PRÉPARATION DE MÉDICAMENTS POUR LE TRAITEMENT DE LA PROLIFÉRATION ET LES MÉTASTASES DES CELLULES CANCÉREUSES DE LA PROSTATE
(ZH) 磷酸二酯酶4抑制剂ZL-n-91在制备治疗前列腺癌增生和转移药物中的应用
Abstract:
(EN) Disclosed in the present invention is an application of a new type of phosphodiesterase 4 (PED4) inhibitor ZL-n-91 in the preparation of a medicament for treating prostate cancer proliferation and metastasis. Animal experiments which utilize mice and cell biological experiments show that, the phosphodiesterase 4 inhibitor ZL-n-91 of the present invention can significantly inhibit the proliferation and metastasis of prostate cancer cells, indicating that the phosphodiesterase 4 inhibitor ZL-n-91 is expected to become an important target of anti-proliferative and metastatic prostate cancer research, which provides the basis for the preparation of anti-prostate cancer proliferation and metastasis drugs; the present invention has good prospects with respect to development and application.
(FR) La présente invention concerne l'application d'un nouveau type d'inhibiteur de phosphodiestérase 4 (PED4), le ZL-n-91, dans la préparation d'un médicament destinés à traiter la prolifération et les métastases des cellules cancéreuses de la prostate. Des expérimentations animales qui utilisent des souris et des expériences biologiques cellulaires démontrent que, ZL-n-91 l'inhibiteur de phosphodiestérase 4 de la présente invention peut inhiber significativement la prolifération et la métastase de cellules cancéreuses de la prostate, ce qui prédit que ZL-n-91 l'inhibiteur de phosphodiestérase 4 peut devenir une cible importante de recherche pour la lutte contre la prolifération et les métastases des cellules cancéreuses de la prostate; qu'il peut servir de base pour la préparation de médicaments luttant contre la prolifération et les métastases des cellules cancéreuses de la prostate; la présente invention présente de bonnes perspectives par rapport au développement et à l'application.
(ZH) 本发明公开了一种新型磷酸二酯酶4(PDE4)抑制剂ZL-n-91在制备治疗抗前列腺癌增殖和转移药物中的应用。利用在小鼠的动物实验和细胞学实验表明本发明所述磷酸二酯酶4抑制剂ZL-n-91可以显著抑制前列腺癌细胞的增殖和转移,预示该磷酸二酯酶4抑制剂ZL-n-91有望成为抗前列腺癌增殖和转移研究的重要靶点,为制备抗前列腺癌增殖和转移药物提供了基础,具有良好的开发应用前景。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)