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1. (WO2018028453) PALLADIUM (II) COMPLEXES CONTAINING N-HETEROCYCLIC CARBENE LIGAND, SYNTHESIS, AND APPLICATIONS IN CANCER TREATMENT
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Pub. No.: WO/2018/028453 International Application No.: PCT/CN2017/095174
Publication Date: 15.02.2018 International Filing Date: 31.07.2017
IPC:
C07F 17/02 (2006.01) ,C07F 17/00 (2006.01) ,A61K 31/435 (2006.01) ,A61K 31/41 (2006.01) ,A61K 31/015 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
17
Metallocenes
02
of metals of the iron group or the platinum group
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
17
Metallocenes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
01
Hydrocarbons
015
carbocyclic
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
THE UNIVERSITY OF HONG KONG [CN/CN]; Pokfulam Road Hong Kong, CN
Inventors:
CHE, Chi Ming; CN
FONG, Tsz Him; CN
LOK, Chun Nam; CN
CHOW, Pui Keong; CN
Agent:
CHINA PATENT AGENT (H.K.) LTD.; 22/F., Great Eagle Center 23 Harbour Road Wanchai Hong Kong, CN
Priority Data:
62/372,38109.08.2016US
Title (EN) PALLADIUM (II) COMPLEXES CONTAINING N-HETEROCYCLIC CARBENE LIGAND, SYNTHESIS, AND APPLICATIONS IN CANCER TREATMENT
(FR) COMPLEXES DE PALLADIUM (II) CONTENANT UN LIGAND CARBÈNE N-HÉTÉROCYCLIQUE, LEUR SYNTHÈSE ET LEURS APPLICATIONS DANS LE TRAITEMENT DU CANCER
Abstract:
(EN) Palladium (II) N-heterocyclic carbene (NHC) complexes which are stable in the presence of biological thiols. A representative complex, [Pd (C^N^N) (N, N'-nBu 2NHC) ] (CF 3SO 3) (Pd1d, HC^N^N = 6-phenyl-2, 2'-bipyridine, N, N'-nBu 2NHC=N, N'-di-n-butylimidazolium), displays potent killing activity toward cancer cell lines but is less cytotoxic toward normal human fibroblast cell lines.
(FR) L'invention concerne des complexes de carbène N-hétérocyclique de Palladium (II) (NHC) qui sont stables en présence de thiols biologiques. Un complexe représentatif, [Pd (C^N^N) (N,N'-nBu 2NHC) ] (CF 3SO 3) (Pd1d, HC^N^N = 6-phenyl-2,2'-bipyridine, N,N'-nBu 2NHC=N,N'-di-n-butylimidazolium), présente une puissante activité de destruction des lignées cellulaires cancéreuses mais est moins cytotoxique pour les lignées cellulaires de fibroblastes humains normales.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)