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1. (WO2018028453) PALLADIUM (II) COMPLEXES CONTAINING N-HETEROCYCLIC CARBENE LIGAND, SYNTHESIS, AND APPLICATIONS IN CANCER TREATMENT
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/028453    International Application No.:    PCT/CN2017/095174
Publication Date: 15.02.2018 International Filing Date: 31.07.2017
IPC:
C07F 17/02 (2006.01), C07F 17/00 (2006.01), A61K 31/435 (2006.01), A61K 31/41 (2006.01), A61K 31/015 (2006.01), A61P 35/00 (2006.01)
Applicants: THE UNIVERSITY OF HONG KONG [CN/CN]; Pokfulam Road Hong Kong (CN)
Inventors: CHE, Chi Ming; (CN).
FONG, Tsz Him; (CN).
LOK, Chun Nam; (CN).
CHOW, Pui Keong; (CN)
Agent: CHINA PATENT AGENT (H.K.) LTD.; 22/F., Great Eagle Center 23 Harbour Road Wanchai Hong Kong (CN)
Priority Data:
62/372,381 09.08.2016 US
Title (EN) PALLADIUM (II) COMPLEXES CONTAINING N-HETEROCYCLIC CARBENE LIGAND, SYNTHESIS, AND APPLICATIONS IN CANCER TREATMENT
(FR) COMPLEXES DE PALLADIUM (II) CONTENANT UN LIGAND CARBÈNE N-HÉTÉROCYCLIQUE, LEUR SYNTHÈSE ET LEURS APPLICATIONS DANS LE TRAITEMENT DU CANCER
Abstract: front page image
(EN)Palladium (II) N-heterocyclic carbene (NHC) complexes which are stable in the presence of biological thiols. A representative complex, [Pd (C^N^N) (N, N'-nBu 2NHC) ] (CF 3SO 3) (Pd1d, HC^N^N = 6-phenyl-2, 2'-bipyridine, N, N'-nBu 2NHC=N, N'-di-n-butylimidazolium), displays potent killing activity toward cancer cell lines but is less cytotoxic toward normal human fibroblast cell lines.
(FR)L'invention concerne des complexes de carbène N-hétérocyclique de Palladium (II) (NHC) qui sont stables en présence de thiols biologiques. Un complexe représentatif, [Pd (C^N^N) (N,N'-nBu 2NHC) ] (CF 3SO 3) (Pd1d, HC^N^N = 6-phenyl-2,2'-bipyridine, N,N'-nBu 2NHC=N,N'-di-n-butylimidazolium), présente une puissante activité de destruction des lignées cellulaires cancéreuses mais est moins cytotoxique pour les lignées cellulaires de fibroblastes humains normales.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)