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1. (WO2018028369) USE OF TNFR2
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Pub. No.:    WO/2018/028369    International Application No.:    PCT/CN2017/092338
Publication Date: 15.02.2018 International Filing Date: 10.07.2017
A61K 45/00 (2006.01), A61K 38/19 (2006.01), A61P 9/10 (2006.01), A61P 9/00 (2006.01)
Applicants: THE FIRST AFFILIATED HOSPITAL, SUN YAT-SEN UNIVERSITY [CN/CN]; No. 58 Zhongshan 2nd Rd Guangzhou, Guangdong 510080 (CN)
Inventors: WANG, Min; (US)
Agent: SCIHEAD IP LAW FIRM; Room 1508 Huihua Commercial & Trade Building No.80 Xian Lie Zhong Road, Yuexiu District Guangzhou, Guangdong 510070 (CN)
Priority Data:
201610653996.5 10.08.2016 CN
201610654249.3 10.08.2016 CN
201710530130.X 29.06.2017 CN
201710530538.7 29.06.2017 CN
(ZH) TNFR2的用途
Abstract: front page image
(EN)Disclosed is a use of TNFR2 as a target in the screening of drugs, such as a TNFR2 activator. The drugs are used for promoting cardiac stem cell activation, migration or survival, promoting differentiation of cardiac stem cells into cardiomyocytes, or promoting myocardial repair, and treating human ischemic heart disease. TNFR2 may also be used as a marker for the preparation of reagents or kits for screening or recognizing cardiac stem cells.
(FR)L'invention concerne l'utilisation de TNFR2 comme cible dans le criblage de médicaments, tels qu'un activateur de TNFR2. Les médicaments sont utilisés pour favoriser l'activation, la migration ou la survie des cellules souches cardiaques, favoriser la différenciation des cellules souches cardiaques en cardiomyocytes, ou favoriser la réparation myocardique, et traiter la cardiopathie ischémique humaine. Le TNFR2 peut également être utilisé comme marqueur pour la préparation de réactifs ou de kits pour le criblage ou la reconnaissance de cellules souches cardiaques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)