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1. (WO2018028369) USE OF TNFR2
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/028369 International Application No.: PCT/CN2017/092338
Publication Date: 15.02.2018 International Filing Date: 10.07.2017
IPC:
A61K 45/00 (2006.01) ,A61K 38/19 (2006.01) ,A61P 9/10 (2006.01) ,A61P 9/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
19
Cytokines; Lymphokines; Interferons
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
10
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
Applicants: THE FIRST AFFILIATED HOSPITAL, SUN YAT-SEN UNIVERSITY[CN/CN]; No. 58 Zhongshan 2nd Rd Guangzhou, Guangdong 510080, CN
Inventors: WANG, Min; US
Agent: SCIHEAD IP LAW FIRM; Room 1508 Huihua Commercial & Trade Building No.80 Xian Lie Zhong Road, Yuexiu District Guangzhou, Guangdong 510070, CN
Priority Data:
201610653996.510.08.2016CN
201610654249.310.08.2016CN
201710530130.X29.06.2017CN
201710530538.729.06.2017CN
Title (EN) USE OF TNFR2
(FR) UTILISATION DE TNFR2
(ZH) TNFR2的用途
Abstract:
(EN) Disclosed is a use of TNFR2 as a target in the screening of drugs, such as a TNFR2 activator. The drugs are used for promoting cardiac stem cell activation, migration or survival, promoting differentiation of cardiac stem cells into cardiomyocytes, or promoting myocardial repair, and treating human ischemic heart disease. TNFR2 may also be used as a marker for the preparation of reagents or kits for screening or recognizing cardiac stem cells.
(FR) L'invention concerne l'utilisation de TNFR2 comme cible dans le criblage de médicaments, tels qu'un activateur de TNFR2. Les médicaments sont utilisés pour favoriser l'activation, la migration ou la survie des cellules souches cardiaques, favoriser la différenciation des cellules souches cardiaques en cardiomyocytes, ou favoriser la réparation myocardique, et traiter la cardiopathie ischémique humaine. Le TNFR2 peut également être utilisé comme marqueur pour la préparation de réactifs ou de kits pour le criblage ou la reconnaissance de cellules souches cardiaques.
(ZH) TNFR2作为靶标筛选药物例如TNFR2激活剂中的用途,所述药物用于促进心脏干细胞活化、迁移或存活,促进心脏干细胞分化为心肌细胞或促进心肌修复,治疗人类缺血性心脏病。TNFR2也可作为标志物用于制备筛选或识别心脏干细胞的试剂或试剂盒。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)