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1. (WO2018028249) MIRNA AND USE THEREOF IN TREATMENT OF METABOLIC DISEASE

Pub. No.:    WO/2018/028249    International Application No.:    PCT/CN2017/081994
Publication Date: Fri Feb 16 00:59:59 CET 2018 International Filing Date: Thu Apr 27 01:59:59 CEST 2017
IPC: C12Q 1/68
A61K 48/00
Applicants: HENAN UNIVERSITY
河南大学
Inventors: CHEN, Weidong
陈卫东
NIE, Xiaobo
聂小博
WANG, Yandong
王艳东
ZHOU, Yun
周云
LV, Xinrui
吕心瑞
Title: MIRNA AND USE THEREOF IN TREATMENT OF METABOLIC DISEASE
Abstract:
A miRNA and use thereof in the preparation of medicaments for treating metabolic diseases. The miRNA is miR-149-3p, and the miR-149-3p comprises a combination of one or more of (a)-(f) as follows: (a) a pri-miRNA of miR-149-3p; (b) a pre-miRNA of miR-149-3p; (c) a mature miRNA of miR-149-3p; (d) a modified miR-149-3p derivative; (e) a miRNA having a core sequence as shown in SEQ ID NO:1, a length of 18-26nt and the same or substantially the same function as miR-149-3p; and (f) a modified derivative of (e) above. Compared with the traditional therapeutic medicaments, the miRNA can inhibit the occurrence and development of metabolic diseases by enhancing the insulin sensitivity of the body, reducing the abnormal accumulation of triglycerides in the liver and reducing the deposition of lipid plaques in the blood vessel, and can be used in the preparation of medicaments for preventing and treating metabolic diseases and in the diagnosis and treatment of metabolic diseases.