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|1. (WO2018028157) VC-CAR MOLECULE AND APPLICATION THEREOF TO HIV-1 INFECTION CELL CLEARING|
|Applicants:||SUN YAT-SEN UNIVERSITY
|Title:||VC-CAR MOLECULE AND APPLICATION THEREOF TO HIV-1 INFECTION CELL CLEARING|
The present invention relates to the technical field of tumor immunotherapy, and particularly a VC-CAR molecule and an application thereof to HIV-1 infection cell clearing are disclosed. The VC-CAR molecule is characterized in that a HIV-1 broad-spectrum neutralizing antibody VRC01 sourced scFv sequence and an intracellular domain sequence of a conventional CAR molecule are connected, and are respectively used as extracellular and intracellular structures. A T cell transformed by the VC-CAR molecule can be specifically activated and secrete a great number of cell factors relevant to cytotoxicity to further powerfully mediate cracking of a targeted cell, and thus the VC-CAR molecule can be better used for anti-infection adoptive immunotherapy.