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1. (WO2018028157) VC-CAR MOLECULE AND APPLICATION THEREOF TO HIV-1 INFECTION CELL CLEARING

Pub. No.:    WO/2018/028157    International Application No.:    PCT/CN2017/072266
Publication Date: Fri Feb 16 00:59:59 CET 2018 International Filing Date: Tue Jan 24 00:59:59 CET 2017
IPC: C07K 19/00
C12N 15/62
C12N 5/10
A61K 35/17
A61P 31/18
Applicants: SUN YAT-SEN UNIVERSITY
中山大学
Inventors: ZHANG, Hui
张辉
LIU, Bingfeng
刘炳峰
ZOU, Fan
邹帆
Title: VC-CAR MOLECULE AND APPLICATION THEREOF TO HIV-1 INFECTION CELL CLEARING
Abstract:
The present invention relates to the technical field of tumor immunotherapy, and particularly a VC-CAR molecule and an application thereof to HIV-1 infection cell clearing are disclosed. The VC-CAR molecule is characterized in that a HIV-1 broad-spectrum neutralizing antibody VRC01 sourced scFv sequence and an intracellular domain sequence of a conventional CAR molecule are connected, and are respectively used as extracellular and intracellular structures. A T cell transformed by the VC-CAR molecule can be specifically activated and secrete a great number of cell factors relevant to cytotoxicity to further powerfully mediate cracking of a targeted cell, and thus the VC-CAR molecule can be better used for anti-infection adoptive immunotherapy.