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1. (WO2018027477) SPIROCYCLIC INDOLONE POLYETHYLENE GLYCOL CARBONATE COMPOUND, COMPOSITION, PREPARATION METHOD AND USE THEREOF

Pub. No.:    WO/2018/027477    International Application No.:    PCT/CN2016/093954
Publication Date: Fri Feb 16 00:59:59 CET 2018 International Filing Date: Tue Aug 09 01:59:59 CEST 2016
IPC: C07D 487/10
C07D 487/04
C07D 487/20
A61K 31/407
A61P 35/00
Applicants: XIAO, Fei
肖飞
Inventors: XIAO, Fei
肖飞
MA, Jie
马洁
XIAO, Fei
肖飞
REN, Hongjun
任红军
WANG, Wei
王玮
XU, Hongtao
许宏涛
WANG, Meng
王萌
ZOU, Lihui
邹丽辉
DING, Fei
丁飞
SU, Fei
苏斐
Title: SPIROCYCLIC INDOLONE POLYETHYLENE GLYCOL CARBONATE COMPOUND, COMPOSITION, PREPARATION METHOD AND USE THEREOF
Abstract:
The present invention relates to a spirocyclic indolone polyethylene glycol carbonate compound, a composition thereof, a preparation method therefor, and a use thereof as an anticancer drug due to the antitumor activity thereof. The structural formula of the spirocyclic indolone polyethylene glycol carbonate compound is shown below. The compound has excellent tumor inhibitory activity, water solubility, low toxicity, and can be used for intravenous injection.