According to one configuration, a system includes sensor hardware and signal processor resource to monitor and analyze bio-media (such as blood and/or other matter) of a person under test. During operation, the sensor hardware monitors the bio-media of the person under test and produces an output. The monitored output (such as one or more signals) varies in magnitude based at least in part on person-induced movement. The signal processor resource analyzes the output produced by the sensor hardware. Based on the analysis, and detected variation in the output of the sensor hardware as caused by the person's movement, the signal processor resource produces a setting for a biometric parameter of interest associated with monitoring the bio-media. Note that the system as described herein can be used to measure different biometric parameters of interest such as venous blood oxygen content, vein stiffness, etc.