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1. (WO2018027223) CAMKK2 INHIBITOR COMPOSITIONS AND METHODS OF USING THE SAME

Pub. No.:    WO/2018/027223    International Application No.:    PCT/US2017/045749
Publication Date: Fri Feb 09 00:59:59 CET 2018 International Filing Date: Tue Aug 08 01:59:59 CEST 2017
IPC: A61K 35/17
A61K 39/395
A61P 35/00
Applicants: DUKE UNIVERSITY
Inventors: RACIOPPI, Luigi
NELSON, Erik
HUANG, Wei
CHAO, Nelson
MCDONNELL, Donald
Title: CAMKK2 INHIBITOR COMPOSITIONS AND METHODS OF USING THE SAME
Abstract:
Provided herein are compositions including a CaMKK2 inhibitor and an anti-cancer therapeutic agent and methods of treating cancer in a subject by administering a therapeutically effective amount of the composition to a subject. The subject may be selected for treatment based on an immune cell measurement of a sample from the subject. Methods of treating cancer by administering a therapeutically effective amount of a CaMKK2 inhibitor, and administering a therapeutically effective amount of an anti-cancer therapeutic agent to the subject are also provided. Kits including combination of a CaMKK2 inhibitor and another anti-cancer therapeutic agent are also provided.