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1. (WO2018027147) AFFINITY MATURATED TAG72 SPECIFIC SINGLE CHAIN ANTIBODIES
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Pub. No.: WO/2018/027147 International Application No.: PCT/US2017/045533
Publication Date: 08.02.2018 International Filing Date: 04.08.2017
IPC:
A61K 39/395 (2006.01) ,C07K 16/30 (2006.01) ,C07K 16/46 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
30
from tumour cells
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46
Hybrid immunoglobulins
Applicants:
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE INC. [US/US]; 12902 Magnolia Drive Tampa, Florida 33612-9497, US
Inventors:
SOLIMAN, Hatem; US
Agent:
GILES, Brian; Thomas Horstemeyer LLP 3200 Windy Hill Road SE, Suite 1600E Atlanta, Georgia 30339, US
Priority Data:
62/371,01804.08.2016US
62/449,89224.01.2017US
Title (EN) AFFINITY MATURATED TAG72 SPECIFIC SINGLE CHAIN ANTIBODIES
(FR) ANTICORPS À CHAÎNE UNIQUE SPÉCIFIQUES DE TAG72 AYANT UNE MATURATION D'AFFINITÉ
Abstract:
(EN) Disclosed are compositions and methods for targeted treatment of TAG-72-expressing cancers. In particular, affinity maturated single chain variable fragment (scFv) antibodies that bind TAG-72 on cancer cells are disclosed.
(FR) La présente invention concerne des compositions et des méthodes pour le traitement ciblé de cancers exprimant TAG-72. En particulier, l'invention concerne des anticorps à fragment variable à chaîne unique (scFv) à maturation d'affinité qui se lient à TAG -72 sur les cellules cancéreuses.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)