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1. (WO2018027147) AFFINITY MATURATED TAG72 SPECIFIC SINGLE CHAIN ANTIBODIES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/027147    International Application No.:    PCT/US2017/045533
Publication Date: 08.02.2018 International Filing Date: 04.08.2017
IPC:
A61K 39/395 (2006.01), C07K 16/30 (2006.01), C07K 16/46 (2006.01)
Applicants: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE INC. [US/US]; 12902 Magnolia Drive Tampa, Florida 33612-9497 (US)
Inventors: SOLIMAN, Hatem; (US)
Agent: GILES, Brian; Thomas Horstemeyer LLP 3200 Windy Hill Road SE, Suite 1600E Atlanta, Georgia 30339 (US)
Priority Data:
62/371,018 04.08.2016 US
62/449,892 24.01.2017 US
Title (EN) AFFINITY MATURATED TAG72 SPECIFIC SINGLE CHAIN ANTIBODIES
(FR) ANTICORPS À CHAÎNE UNIQUE SPÉCIFIQUES DE TAG72 AYANT UNE MATURATION D'AFFINITÉ
Abstract: front page image
(EN)Disclosed are compositions and methods for targeted treatment of TAG-72-expressing cancers. In particular, affinity maturated single chain variable fragment (scFv) antibodies that bind TAG-72 on cancer cells are disclosed.
(FR)La présente invention concerne des compositions et des méthodes pour le traitement ciblé de cancers exprimant TAG-72. En particulier, l'invention concerne des anticorps à fragment variable à chaîne unique (scFv) à maturation d'affinité qui se lient à TAG -72 sur les cellules cancéreuses.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)